Bristol-myers Squibb Compnay

Other

Kenton L Shultis

Daniel A Benigni

Henry S Wong

Norman A Goldschmidt

Connie Esenther

Gary V Faigle

There is disclosed a high containment device, apparatus or system for withdrawing sample material from process or manufacturing equipment with substantially no leakage of the sample material to the external environment and which is of syringe-type construction, thus preventing possible contamination of such environment or workers operating processing and/or production equipment in such a situation, especially where hazardous materials are involved. The high containment device, apparatus or system disclosed is used in combination with process or manufacturing equipment thus providing a system which results in the prevention of leakage of possible hazardous material to the environment and possible contamination of equipment operators thereby.

High containment sampler

Apparatus is provided for charging a bioreactor with feed material through a sight port in the bioreactor vessel wall without compromising sterility of the material or the vessel or releasing organisms from the vessel to the surrounding atmosphere.

Sanitary carbon charging system

7-(Diphenylmethyl)oxy-9a-methoxymitosane is a novel intermediate for conversion into 7-amino and 7-oxy-9a-methoxymitosanes and is also useful for inhibiting mammalian tumor growth. The compound is prepared by reacting 7-hydroxy-9a-methoxymitosane with diazodiphenylmethane. In a preferred reaction, the compound is prepared from mitomycin C via 7-hydroxy-9a-methoxymitosane without drying (water removal). The intermediate is advantageously converted to the very effective anti-tumor agent 7-[2-(4-nitrophenyldithio)ethylamino]-9a-methoxymitosane in unexpectedly high yields using a two step process where the first step constitutes conversion to 7-[2-(2-pyridyldithio)ethylamino]-9a-methoxymitosane or 7-[2-(3-nitro-2-pyridyldithio)ethylamino]-9a-methoxymitosane.

Process for preparing dithio-ethylanino 9A-methoxymitosanes

7-(Diphenylmethyl)oxy-9a-methoxymitosane is a novel intermediate for conversion into 7-amino and 7-oxy-9a-methoxymitosanes and is also useful for inhibiting mammalian tumor growth. The compound is prepared by reacting 7-hydroxy-9a-methoxymitosane with diazodiphenylmethane. In a preferred reaction, the compound is prepared from mitomycin C via 7-hydroxy-9a-methoxymitosane without drying (water removal). The intermediate is advantageously converted to the very effective anti-tumor agent 7-[2-(4-nitrophenyldithio) ethylamino]-9a-methoxymitosane in unexpectedly high yields using a two step process where the first step constitutes conversion to 7-[2-(2-pyridyldithio) ethylamino]-9a-methoxymitosane. or 7-[2-(3-nitro-2-pyridyldithio)ethylamino]-9a-methoxymitosane.

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Manlius, NY, United States of America

Kenton L Shultis