Daiichi Sankyo Company, Limited

Kentoku Gotanda

Kazumasa Aoki

Yoshiharu Hiruma

Akira Nakao

Shimpei Hirano

Takeshi Shiiki

Tomio Kimura

Kazuki Yano

Katsuhiro Kawakami

Koji Suda

Toshihiro Kiho

Atsushi Tengeiji

Compounds or pharmacologically acceptable salts thereof for promoting osteogenesis, improving bone metabolism, preventing or treating bone fracture, preventing or treating a disease associated with bone metabolism, or in the field of orthopedics for the promotion of healing of bone fracture, a bone defect, and bone diseases such as osteoarthritis as well as in the field of dentistry for the treatment of periodontal disease and the stabilization of artificial tooth root. The compounds are represented by formula (I) or a pharmacologically acceptable salt thereof: 

Chromone derivative having osteogenesis promoting effect

It is an object of the present invention to provide a substituted propanamide derivative or a pharmacologically acceptable salt thereof that is useful as a prophylactic or therapeutic agent for a bone metabolic disease. The present invention relates to a pharmaceutical composition comprising a compound having General Formula (I) or a pharmacologically acceptable salt thereof as an active ingredient: [wherein, Rrepresents a C-Caryl group that may be substituted by a group selected from Substituent Group &#x3b1;, for example; Rrepresents a C-Caryl group that may be substituted by a group selected from Substituent Group &#x3b1;, for example; and X represents a hydroxyl group or a C-Calkoxy group, for example].

Substituted propanamide derivative and pharmaceutical composition containing the same

Compounds exhibiting calcium receptor antagonist activity that are safe and orally administrable having Formula (I) or pharmaceutically acceptable salts thereof: 

Indanyl compounds

Compounds exhibiting calcium receptor antagonist activity that are safe and orally administrable having Formula (I) or pharmaceutically acceptable salts thereof 

Cyclic amine compounds

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Chiba, Japan

Kentoku Gotanda