Board of Trustees of the University of Arkansas

The Kitasato Institute

Kagawa University

School Juridical Person Kitasato Institute

National University Corporation Kagawa Univesity

Kentaro Uchida

Osamu Matsushita

Joshua Sakon

Keisuke Tanaka

Nozomu Nishi

Takashi Haraguchi

Ryan Bauer

Jeffrey Roeser

Koji Naruse

Katarzyna Janowska

Masashi Takaso

Takehiko Mima

The invention generally relates to collagen-binding agent compositions and methods of using the same. More specifically, the invention relates in part to new collagen-binding agent compositions and methods that may be used to treat damaged collagen within tissues or used to specifically target therapeutics to tissues containing undamaged or damaged collagen.

Collagen-binding agent compositions and methods of using the same

Provided is a growth factor anchoring type bone graft material, wherein a bone graft substrate exposing at least a collagen fiber is bound to a collagen-binding-site-containing growth factor which contains a growth factor receptor agonist peptide and a collagen-binding peptide. The same can be produced by mixing a bone graft substrate and a collagen-binding-site-containing growth factor which contains a growth factor receptor agonist peptide and a collagen-binding peptide, and is also superior in osteogenic ability.

Growth factor anchoring type bone graft material, method for producing growth factor anchoring type bone graft material, kit for producing growth factor anchoring type bone graft material, and method for forming bone

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Sagamihara, Japan

Kentaro Uchida