Fujifilm Corporation

Fujifilm Toyama Chemical Co., Ltd.

National Institute of Advanced Industrial Science and Technology

Kentaro Furuya

Tadashi Tanaka

Muneo Shoji

Masataka Fujino

Kei Matsuura

Tohru Natsume

Tetsuya Matsushita

Hirofumi Omura

Keiko Makita

Hiromi Hayashi

Kazunori Saeki

Tomofumi Nakae

An object of the present invention is to provide a compound and a pharmaceutical composition which exhibit strong antibacterial activity against Gram-negative bacteria and drug-resistant Gram-negative bacteria. A compound represented by General Formula [1](the reference signs in Formula have the same definitions as those described in the present specification) or a salt thereof has strong antibacterial activity against Gram-negative bacteria such asand drug-resistant Gram-negative bacteria including multidrug-resistant, and the pharmaceutical composition containing the compound or a salt thereof is useful as an antibacterial agent.

Penam derivative or salt thereof, pharmaceutical composition, and applications thereof

An object of the present invention is to provide a compound and a pharmaceutical composition which exhibit strong antibacterial activity against Gram-negative bacteria and drug-resistant Gram-negative bacteria. According to the present invention, a compound represented by General Formula [1] (the reference signs in the formula have the same definitions as those described in the present specification) or a salt thereof has strong antibacterial activity against Gram-negative bacteria such asand drug-resistant Gram-negative bacteria including multidrug-resistant, and the pharmaceutical composition containing the compound or a salt thereof is useful as an antibacterial agent. 

2-carboxypenam compound or salt thereof, pharmaceutical composition containing novel 2-carboxypenam compound or salt thereof, and applications thereof

It is an object of the present invention to provide an antitumor agent, which is further excellent as a treatment agent used in the prevention and/or therapy of tumor associated with a bromodomain, and also to provide a bromodomain inhibitor, which is useful as a treatment agent for diseases or states associated with a bromodomain. An antitumor agent and a bromodomain inhibitor, comprising a compound represented by the following formula, have an excellent bromodomain inhibitory activity and are useful as treatment agents in the prevention and/or therapy of tumor associated with a bromodomain, and the like: 

Antitumor agent and bromodomain inhibitor

A compound represented by the general formula, or a salt thereof, has exceptional CXCL10 inhibitory activity and is useful as a treatment agent for the prevention and/or treatment, etc., of diseases involving overproduction of CXCL10. In the formula: Ris a Calkyl group, etc.; Ris a hydrogen atom, etc.; Ris a halogen atom, etc.; Z, Z, and Zare CH, etc.; Xis CONH, etc.; ring A is a phenyl group, etc.; Ris a halogen atom, etc.; and m is an integer of 0-5. 

Nitrogen-containing heterocyclic compound

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Toyama, Japan

Kentaro Furuya