Chugai Seiyaku Kabushiki Kaisha

Kenta Wada

Kenichi Sakai

Tomoaki Hirayama

Shiho Yoshimura

Takeshi Nakamura

Toshinari Taira

Katsuya Otomo

The present invention provides a method for producing a pharmaceutical composition which is a tablet and which contains tofogliflozin as an active ingredient. The method comprises mixing an additive and tofogliflozin to prepare a powder mixture and obtaining a tablet from the powder mixture by direct compression. The additive comprises at least one filler.

Solid preparations containing tofogliflozin and process of producing the same

In manufacturing an aspherical seamless capsule comprises, firstly, a seamless capsule Chaving a filler encapsulated with a shell membrane is provided, then it is dried in a dryeruntil a predetermined percentage content of solvent in the shell membrane reaches a predetermined value. Subsequently, the seamless capsule is heated by a heaterso that the shell material may get to a semi-sol state. Then, the heated seamless capsule is formed into an aspherical shape using a forming machine such as a compression molding machine. Because the spherical seamless capsule has a shell membrane which is dried to get semi-sol so that it may have a reduced elasticity and a shortened stress relaxation time, the capsule can be formed in a short time and suppressed from restoring to the original spherical shape. The semi-sol shell membrane has almost no change in properties, and so allows easiness in temperature control for treatment. The aspherical capsule after being formed does not or rarely need drying, resulting in wrinkle resistance and little variation in shape brought on the surface of the shell membrane.

Process for producing aspheric seamless capsule and apparatus therefor

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Tokyo, Japan

Kenta Wada