Stauffer Chemical Company

Kent E Matsumoto

Don R Baker

Ferenc M Pallos

Jack R DeBaun

Laddie L Green

Jimmy H Chan

John H Ross

Herbicide antidote compounds having the formula ##STR1## in which X and X' are halogens, independently selected from the group consisting of chlorine, bromine and iodine; and

Dihalopropyl ester herbicide antidotes

Novel compounds having the structural formula ##STR1## wherein R.sub.1 and R.sub.2 are independently selected from the group consisting of hydrogen, halo, alkyl, haloalkyl, thioalkyl, thiohaloalkyl, alkoxy, cyano and nitro are provided. The compounds have various pharmacological effects, including cardiotropic, hypoglycemic, hypocholesterolemic and/or antiulcerative effects in mammals. Methods of achieving these various pharmacological effects in mammals by administering the compounds thereto are provided. Pharmaceutical compositions and formulations including the compounds are provided along with methods of synthesis of the novel compounds.

Pyrrolid-3-en-2-ones and pharmaceutical methods of use thereof

Antidote compounds for use with acetanilide herbicides having the formula ##STR1## in which X and X' are halogens, independently selected from the group consisting of chlorine, bromine, and iodine; and

Dihalopropyl ester antidotes for acetanilide herbicides

1,3-dichloroacetone oxime is prepared from 1,3-dichloropropanone by reaction with a hydroxylamine salt in a strongly acidic medium in the presence of a base selected from the group consisting of tertiary amines, lower alkyl amides, alkali metal bicarbonates, alkali metal carbonates and alkaline earth metal carbonates. 1,3-dichloroacetone oxime acetate is advantageously prepared by reaction of the oxime with acetic anhydride. The acetate is obtained in high purity.

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Kensington, CA, United States of America

Kent E Matsumoto