Olympus Corporation

The University of Tokyo

Daiichi Sankyo Company, Limited

Olympus Medical Systems Corporation

Kensuke Miyake

Fumiyuki Onoda

Chieko Aizawa

Minoru Sato

Hiroshi Niwa

Yoshitaka Miyoshi

Tomohiko Oda

Atsuo Kanno

Yusuke Murakami

Yuji Motoi

Kensuke Nakamura

Takashi Isobe

Toshiyuki Shimizu

Takaichi Shimozato

Takashi Kagari

Jun Ishiguro

Atsushi Manno

Umeharu Ohto

Takashi Saito

Masahiro Katakura

Hiroyuki Ushifusa

Akira Murata

Keijiro Omoto

Takashi Yamashita

Isamu Nakajima

Ryu Oshima

Yugo Koizumi

Mai Ojima

Takechiyo Nakamitsu

Tsukasa Ishii

Kazutaka Tuji

Akihiro Miyashita

Ryutaro Fukui

Masahiro Onji

Kazuhiro Hata

The present invention provides a pharmaceutical composition comprising an antibody which binds specifically to human TLR7 or monkey TLR7 and does not bind to mouse TLR7 or rat TLR7, and has an activity of inhibiting a function of human TLR7 or monkey TLR7, and the like.

Anti-human TLR7 antibody

An endoscope insertion observation apparatus includes a processor designed to perform functions including: detecting an insertion state of an insertion portion of an endoscope that is insertable into and extractable from a subject; determining whether or not the insertion portion has reached a second site in the subject from a first site in the subject and/or whether the insertion portion has reached the first site from the second site in the subject based on a detection result of the insertion state; and calculating a duration of movement of the insertion portion from the first site to the second site after determining that the insertion portion has reached the second site, or a duration of movement of the insertion portion from the second site to the first site after determining that the insertion portion has reached the first site.

Endoscope insertion observation apparatus capable of calculating duration of movement of insertion portion

The present invention provides a novel antibody targeting TLR9.

Anti-TLR9 antibody, pharmaceutical composition, and kit

An endoscope apparatus including a connector included in an endoscope and connected to an endoscope connection portion of a video processor, a fluid feeding apparatus including a tube configured to transmit fluid to the endoscope, a connection detector configured to detect a connection state of the tube with the connector of the endoscope, a control unit configured to detect an ON/OFF state of a power source of the fluid feeding apparatus, determine an abnormality exists when the connection detector detects that the tube is in a disconnected state with the connector of the endoscope and the power source of the fluid feeding apparatus is detected to be in an ON state, and output a notification of the determined abnormality, and a display configured to display the notification of the abnormality outputted by the control unit.

Endoscope apparatus, activation method, and video processor for determining an abnormality

An object of the present invention is to provide a highly-safe and highly-specific preventive or therapeutic agent for inflammatory diseases targeting a TLR7 or TLR9 molecule. The present invention provides a preventive or therapeutic agent for inflammatory diseases containing an anti-TLR7 antibody or anti-TLR9 antibody.

Preventive or therapeutic agent for inflammatory disease

An endoscope insertion shape observation apparatus includes an endoscope, a magnetic field generation coil provided at an insertion portion of the endoscope and configured to generate a magnetic field, an antenna unit configured to receive a coil signal from the magnetic field generation coil, a bending portion configured to bend the insertion portion, a bending drive section configured to drive the bending portion to bend, an insertion shape processing circuit configured to generate an insertion shape of the endoscope inserted into a subject according to a signal received from the antenna unit, a touch panel configured to display a generation result of the insertion shape processing circuit and be able to perform touch operation, and a drive section control circuit configured to control a drive amount of the bending drive section based on the touch operation on a desired location of the insertion shape displayed on the touch panel.

Endoscope insertion shape observation apparatus having a controller to drive bending of insertion portion of endoscope

A detecting apparatus includes: a change-over switch for switching on/off display of a scope model on a liquid crystal monitor; a position calculating portion for calculating respective positions of source coils; a scope model generating portion for generating a scope model of an electronic endoscope based on the respective positions of the source coils calculated by the position calculating portion; and a selector for selectively outputting to the liquid crystal monitor a display-pause-time image stored in a display-pause-time image storing portion and a scope model image from the scope model generating portion; and a control portion for controlling each of these portions. The detecting apparatus thus displays an insertion shape of the endoscope at a timing as needed.

Endoscope shape detecting apparatus

An endoscope inserted-shape detecting apparatusincludes a sense coil unitin which multiple sense coil groups of sense coil groupsA toI for detecting magnetic fields generated by multiple source coilsin an inserted-shape detecting probeare placed as a part of the endoscope inserted-shape detecting apparatus, a signal detecting section, a source coil position analyzing sectionand a signal control sectionthat selects a magnetic-field detecting element to be used for detection of a magnetic field signal based on the magnetic field generated by each of the source coilsfrom the sense coil groupsA toI in a control section based on positional information signals outputted from the source coil position analyzing section

Endoscope inserted-shape detecting apparatus

A driving block includes a plurality of magnetic-field generating elements and a driving signal generating section, and the magnetic field generated by the plurality of magnetic-field generating elements is detected by a plurality of magnetic-field detecting elements. A shape calculating block calculates a shape of an insertion portion of an endoscope based on a frequency component corresponding to a frequency of the driving signal in a detection signal detected by the plurality of magnetic-field detecting elements. Oscillation frequency of the reference clock for deciding the frequency of the driving signal is changeably set by the frequency setting section, and the reference clock with oscillation frequency set by the frequency setting section is supplied to both of the driving block and the shape calculating block.

A source coil drive circuit section of an endoscope shape detection device includes, an oscillator that generates a sine wave and an amplifier that amplifies the sine wave and generates (drives) an alternating magnetic field to source coils through a switch section. The switch section is configured to switch a direct current to an output of the amplifier and supply to the source coils. In the source coil drive circuit section, a direct current resistance value detection section for measuring a direct current resistance value of the source coils by voltage drop when the switch section is supplying the direct current to the source coils is provided.

Endoscope shape detection device

A medical system control device comprises a first control unit for controlling at least a power supply to a plurality of devices configuring a medical system, a second control unit, the startup process time of which is longer than the first control unit, for controlling the entire medical system, and a storage unit for storing information at the time of an operation termination process for the medical system, which is performed by the second control unit. The first control unit controls a power supply to a predetermined device among the plurality of devices before the startup process of the second control unit is complete, according to the information stored in the storage unit in response to the power-on of the medical system.

Medical system control device

Growing community of inventors

Tokyo, Japan

Kensuke Miyake