Nof Corporation

Other

Kyowa Medex Co., Ltd.

Tfb, Inc.

Kenshiro Shuto

Shujiro Sakaki

Kazuhiko Ishihara

Nobuo Nakabayashi

Ken Suzuki

Satoshi Yamada

Nobuyuki Sakamoto

Shinji Tanaka

Hiroki Fukui

Akio Hayashi

Yasumi Koinuma

Atsuhiko Ogura

Motohiro Mitani

Koji Miyamoto

Nobuyuki Yamamoto

Kayoko Shigenobu

Kazuo Matsuyama

Hirofumi Irie

Mamoru Tsuchida

Yoshimi Sekine

Mitsuo Isomura

Yoshihiro Ashihara

Eui-Chul Kang

Daisuke Kayaba

The present invention relates to an inhibitor capable of increasing accuracy of the reaction in hybridization, and inhibiting nonspecific hybridization, a clinical diagnostic reagent, and a method of clinical analysis whereby nonspecific hybridization in clinical analysis is inhibited, and a target nucleic substance is detected easily with high accuracy. The inhibitor and the clinical diagnostic reagent contains polymer (H) having a nonspecific hybridization inhibitory action. The polymer has in its molecule at least one of carboxyl and sulfone groups, and phosphorylcholine-like groups, and has a weight average molecular weight of 1000 to 5000000. The method of clinical analysis includes contacting a sample with a test agent capable of hybridizing with a specific nucleic substance in the presence of the inhibitor.

Nonspecific hybridization inhibitors, clinical examination reagents and clinical examination method

An agitation method for mixing a solution and a solvent to precipitate a solid substance from the solution. The method includes preparing an agitation mixer including an agitation vessel, an impeller rotated in the agitation vessel, and a feed pipe connected to the agitation vessel and having a multiple pipe structure including an outer pipe and an inner pipe arranged in the outer pipe. A shearing clearance is formed in the agitation vessel between the impeller and the feed pipe. The method further includes shearing the solution and the solvent by rotating the impeller to precipitate the solid substance while feeding the solution and the solvent into the shearing clearance from the outer pipe and the inner pipe.

Agitation mixer and feed pipe structure

The invention provides a quick-drying disinfectant gel for hands that spreads well in rubbing into hands, spreads easily over the hands, forms no scum, and is not sticky before and after drying. The disinfectant gel for hands of the invention contains 0.01 to 2.0 wt % of a maleic anhydride polymer, 0.01 to 5.0 wt % of polysaccharides, 40 to 95 wt % of a lower alcohol, and water, with the total being 100 wt %.

Disinfectant gel for hands

The present invention provides an agglutination immunoassay, wherein the agglutination of insoluble carrier particles such as latex are stabilized and uniformized to give good reproducibility, and a reagent therefor. In the agglutination immunoassay which comprises allowing an antigenic substance in a sample to bind to insoluble carrier particles carrying substantially neither antigens nor antibodies thereon, and allowing an antibody or an antibody complex which reacts specifically to the antigenic substance to bind to the antigenic substance to give a selective agglutination of the insoluble carrier particles, a homopolymer prepared by polymerization of a monomer such as 2-methacryloyloxyethyl phosphorylcholine having a phosphorylcholine group and a vinyl group, or a copolymer prepared by polymerization of a monomer having a phosphorylcholine group and a vinyl group, with a monomer having a vinyl group such as n-butyl methacrylate is used.

Highly reproducible agglutination immunoassay method and reagents

A composition for hydrogels which comprises (A1) a copolymer which comprises 25 to 97 mol % of unit (a) derived from a compound represented by formula (1) and 3 to 75 mol % of unit (b) derived from a monomer represented by formula (2) and is soluble in aqueous media and (B) a polymer which has hydrophilic groups such as hydroxyl or carboxyl groups and is soluble in aqueous media; and a hydrogel comprising the composition. (X represents a divalent organic residue; Y represents alkyleneoxy, etc.; Z, R, R, R, R, and Leach represents hydrogen, etc.; and Lrepresents &#x2014;CH&#x2014;, etc.)

Composition for hydrogel, hydrogel and use thereof

Medical materials and process for producing the same

A wound-covering agent containing a polymer having a group represented by formula (I) (wherein R , R and R are the same or different and each represents hydrogen atom or C alkyl, and m is an integer of 2 to 4); a wound-covering material containing the preparation; and a method of wound healing which comprises the step of covering the wound of a subject with the wound-covering material to protect the wound.

Wound-covering preparation, wound-covering material, and method of wound healing

A method for producing an aqueous solution of a polymer having a phosphorylcholine group in which a polymerizable composition containing a polymerizable monomer having the phosphorylcholine group represented by the formula (1) is polymerized in the presence of a non-metal polymerization initiator soluble in a water-containing medium, to obtain a crude polymer aqueous solution, and the crude polymer aqueous solution is purified with a separation membrane, and an aqueous solution of the polymer having the phosphorylcholine group obtained by the method and having not more than 2000 ppm of impurities.

Method for producing aqueous solution of polymer having phosphorylcholine groups

A polymerized product of protein, comprising a polymer of one or more protein-containing monomers represented by the general formula

Polymerized product of protein and process for producing it

Growing community of inventors

Tsukuba, Japan

Kenshiro Shuto