Eisai R&d Management Co., Ltd.

Kenshi Yoshida

Arani Chanda

George Moniz

Kristen Sanders

Ikuo Kushida

John JianShi Wang

Ming-Hong Hao

Dominic J Reynolds

Nobuaki Sato

Sudeep Prajapati

Takashi Satoh

Yoshiaki Ohashi

Anand Selvaraj

Masaharu Gotoda

Tamaki Hoshikawa

Shunsuke Ozaki

Nao Shibuguchi

A number of crystalline forms of N-(2-((6-(3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-methylureido)pyrimidin-4-yl)amino)-5-(4-ethylpiperazin-1-y1)phenyl)acrylamide are provided. These include a crystalline free base form, a crystalline monohydrochloride salt form, a crystalline dihydrochloride salt form, and a crystalline ethanesulfonate salt form. Methods of making and using crystalline compounds are also provided.

Crystalline FGFR4 inhibitor compound and uses thereof

Salts of the compound represented by formula (I) or crystals thereof have a potential use as drug substances for pharmaceuticals. 

Salt of pentacyclic compound and crystal thereof

A number of crystalline forms of N-(2-((6-(3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-methylureido)pyrimidin-4-yl)amino)-5-(4-ethylpiperazin-1-yl)phenyl)acrylamide are provided. These include a crystalline free base form, a crystalline monohydrochloride salt form, a crystalline dihydrochloride salt form, and a crystalline ethanesulfonate salt form. Methods of making and using crystalline compounds are also provided.

The present invention provides salts consisting of an organocarboxylic acid selected from the group consisting of succinic acid and maleic acid and a compound represented by formula (I) and crystals thereat which can be used as bulk materials for pharmaceuticals.

Salt of monocyclic pyridine derivative and crystal thereof

An organic carboxylic acid salt of 2-[(3S,4R)-1-{[2-chloro-6-(trifluoromethyl)phenyl]methyl}-3-{[1-(cyclohex-1-en-1-ylmethyl) piperidin-4-yl]carbamoyl}-4-methylpyrrolidin-3-yl]acetic acid and a crystal thereof.

Salt of pyrrolidin-3-yl acetic acid derivative and crystals thereof

The invention provides an amorphous form of 4-(3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy)-7-methoxy-6-quinolinecarboxamide.

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Tsukuba, Japan

Kenshi Yoshida