Auburn University

The University of North Carolina at Chapel Hill

Florida State University Research Foundation, Inc.

Edward Via Virginia College of Medicine

Edward Via College of Osteopathic Medicine—auburn

Kenny V Brock

Richard Ray Tidwell

David W Boykin

W David Wilson

Christine C Dykstra

Chad F Stephens

David A Stringfellow

Arvid Kumar

Maurice Daniel Givens

Alexandre M Samoylov

Tatiana I Samoylova

Michael Edgar Zabala

Anna M Cochran

Vitale Kyle Castellano

James W Gillespie

Thomas E Burch

Sara Ziska

Hayden Burch

Jonathan Commander

Disclosed are recombinant bacteriophage constructs and related exogenous peptide sequences for generating immune responses against CD47. The disclosed recombinant phage constructs bind to antibodies against CD47 and can be administered to an animal to generate an immune response against CD47, including generating anti-CD47 antibodies. The disclosed recombinant phage may comprise an amino acid sequence of CD47, epitopic fragments, variants, or functional mimics thereof. Also disclosed are methods for making and selecting such recombinant phage constructs and compositions that comprise such constructs (e.g., compositions for inducing an immune response against CD47 including pharmaceutical or veterinary compositions used as vaccines). Also disclosed are recombinant polynucleotides comprising genomic nucleic acid of the recombinant phage constructs disclosed herein.

Phage-peptide constructs for stimulating an immune response against CD47

Disclosed herein is a device for repeatably and accurately measuring the threshold sensitivity of the skin on a body part or surface such as the plantar surface of the foot. The machine uses a monofilament pressure test, where a monofilament is applied to the surface of the skin until it buckles at a corresponding force. The device may measure a broad range of pressures and responsive sensation in the patient using multiple applications of the monofilament. The patient indicates a positive or negative response, based on whether the patient sensed the monofilament pressure. The machine may include a foot clamping assembly, a support chassis, a linear motion translation assembly for locating the monofilament at a given position for testing, and a camera for taking images used to identify testing locations and report results. Methods of use and testing protocols are also described herein.

Semi-automated plantar surface sensation detection device

Methods of and apparatuses for equine plasma collection are provided. Modified plasmapheresis instruments and modified disposable plasmapheresis tubing are introduced. By using the modified procedures and instruments, a high-speed, high volume, continuous-flow process of automated equine plasmapheresis is developed. The modified closed systems remove whole blood from the donor horses, separate plasma from the cellular components of blood, and simultaneously returning concentrated cells back to the donor horses.

Method and apparatus for equine plasmapheresis

Disclosed are compositions and methods for treating a subject infected withor at risk for infection with. The compositions include and the methods utilize isolated or purified equine antisera against

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The present invention relates to novel compounds and methods that are useful in treating members of the Flaviviridae family of viruses. Compounds of the present invention will have a structure according to Formulas (I)-(VI) as recited throughout the application.

Compounds, methods and compositions useful for the treatment of bovine viral diarrhea virus (BVDV) infection and hepatitis C virus (HCV) infection

The present invention relates to novel compounds and methods that are useful in treating members of the Flaviviridae family of viruses. Compounds of the present invention will have a structure according to Formulas (I)&#x2013;(VI) as recited throughout the application.

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Notasulga, AL, United States of America

Kenny V Brock