Codexis, Inc.

Kenneth W Mitchell

Richard John Fox

Ranjini Chatterjee

Emily Mundorff

Jovana Nazor

Fernando Valle

Jonathan Vroom

Louis Clark

Ish Kumar Dhawan

Matthew B Tobin

Birthe Borup

Claus M Krebber

Kristian Karlshoej

Kaman Chan

Michelle M Chen

Yoram Barak

Svetlana Balatskaya

Les Partridge

Susan Y Louie

The invention generally relates to the production of a fatty alcohol composition from recombinant microbial cells. The fatty alcohols are produced by expressing a gene encoding a heterologous fatty alcohol forming acyl-CoA reductase ('FAR'); a gene encoding a heterologous thioesterase ('TE') gene and a gene encoding an acyl-CoA synthetase (&#x201c;ACS&#x201d;).

Production of fatty alcohols from engineered microorganisms

The present disclosure relates generally to polypeptides having improved alanine 2,3-aminomutase (AAM) activity, the polynucleotides encoding the AAM polypeptides, and expression vectors and host cells for expressing the AAM polypeptides.

Alanine 2,3-aminomutases and related polynucleotides

The present invention is directed to polypeptides that have enhanced alanine 2,3-aminomutase (AAM) activity and/or thermostability relative to the wild-type enzymes that have incidental AAM activity as a result of cross reactivity with alanine. In addition, the present invention is directed to a polynucleotides that encodes for the AAM polypeptides of the present invention, to nucleic acid sequences comprising the polynucleotides, to expression vectors comprising the polynucleotides operatively linked to a promoter, to host cells transformed to express the AAM polypeptides, and to a method for producing the AAM polypeptides of the present invention.

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Sunnyvale, CA, United States of America

Kenneth W Mitchell