Abbott Laboratories Corporation

Immunetech Pharmaceuticals

Kenneth W Funk

James J Napier

Edwin O Lundell

Michael A Staeger

Vimal Kishore

Jane L Chang

Robert B Miller

Wenying Z Gifford

John C Tolle

A method is provided for preparing decapeptide and undecapeptide derivatives of LHRH by solution phase peptide chemistry as well as intermediate peptides useful in the same method.

Process and intermediates for the synthesis of LHRH antagonists

Process for intermediates for the synthesis of LHRH antagonists

A method of synthesizing commercial quantities of the pentapeptide L-aspartyl-L-seryl-L-aspartyl-L-prolyl-L-arginine, and salts or solvates thereof, e.g., the hydrochloride or acetate salt or water solvate, compounds useful in pharmaceutical compositions for the treatment of allergic conditions, is disclosed, as are novel intermediate compounds produced in the course of the synthesis.

Pentapeptide synthesis

Growing community of inventors

Lindenhurst, IL, United States of America

Kenneth W Funk