Amf Gmbh

Cuno, Inc.

Kenneth Southall

Timothy J Webster

Chaokang Chu

Gordon Leeke

Vish Rai

Nils Dailey

Vishva Rai

A chromatography column for effecting chromatographic separation of at least two components of a sample flowing through the column. The column comprises a housing and at least one solid stationary phase within the housing. The stationary phase has chromatographic functionality and is effective for chromatographic separation. Means are provided for distributing the sample through the stationary phase and for collecting the sample after the sample has flowed through the stationary phase. The stationary phase comprises:

Chromatography column

A multicartridge chromatography cartridge housing for use in supporting several chromatography cartridges in a parallel array is disclosed. A number of elongated cylindrical cartridge holders extend between a lower support plate and an upper support plate. Each such cartridge holder receives a chromatography cartridge which is held within the holder by suitable end caps and tie rods. Several truss rods serve to space the support plates from each other and to support the housing assembly. Fluid flow manifolds are secured to the lower and upper support plates and serve to distribute the fluid to, and consolidate the fluid received from the cartridges within the individual holders. The multicartridge chromatography cartridge housing in accordance with the present invention handles high fluid flow volumes with a small pressure drop and with a minimum hold up volume.

Multicartridge chromatography cartridge housing

A method is provided for making a filter cell comprised of two cellulosic fiber containing filter media having a sealed periphery. The method comprises compressing the peripheries of each filter media, to form a flange. The media are then aligned to provide intimate face-to-face contact between the flanges. A spacer means is provided between the media to cause each to dish outwardly from the other media. The two media and spacer means are then placed into a mold surrounding the flanges. The mold has a means for providing a recompression force to the inner portions of the flanges. A thermoplastic polymer is then injected into the mold to form a seal around the flanges. The recompression force is sufficient to maintain the flanges in intimate face-to-face contact with each other and to prevent seepage of the polymer between the flanges when the polymer is injected into the mold. The sealed periphery is reliable, economical to produce, resistant to cracking, provides enhanced support for the filter media, and permits the production of a filter cell having low extractables.

Method of making filter cell having sealed periphery

The invention relates to a shut-off valve assembly for use with a filter carriage where the upper portion of the filter cartridge cooperates with the valve assembly for controlling fluid flowing into and out of the inlet and outlet port of the cartridge once the cartridge is removed from service. Cartridge removal causes the shut-off valve to automatically close fluid flow into and out of the cartridge. A valve abutment member in the shut-off assembly serves to shut off fluid inlet flow and a sealing member on a support member of assembly, serves to seal the shut-off assembly at the fluid inlet port. A ball check mounted in a retainer of assembly is biased in the downward direction during fluid shut-off.

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Wethersfield, CT, United States of America

Kenneth Southall