Atrix Laboratories, Inc.

Vipont Pharmaceutical, Inc.

Kenneth S Peterson

Richard L Dunn

Richard L Norton

Deryl D Swanbom

Alan M Polson

Bryan K Lowe

Charles P Cox

Ronald J Harkrader

Richard R Jones

The invention is directed to a biodegradable implant precursor having a two-part structure made of an outer sac and a liquid content. The implant precursor is composed of a biodegradable, water-coagulable thermoplastic polymer and a water-miscible organic solvent. When administered to an implant site in an animal, the implant precursor will solidify in situ to a solid, microporous matrix by dissipation of the organic solvent to surrounding tissue fluids and coagulation of the polymer. The invention also includes methods of making the implant precursor, an apparatus for forming the precursor, and a kit containing the apparatus. Also provided are methods of using the implant precursor for treating a tissue defect in an animal, for example, for enhancing cell growth and tissue regeneration, wound and organ repair, nerve regeneration, soft and hard tissue regeneration, and the like, for delivery of biologically-active substances to tissue or organs, and other like therapies.

Biodegradable implant precursor

Method and composition for treating a bone tissue defect

Apparatus for forming a biodegradable implant precursor

Mouthrinses containing sanguinarine of superior efficacy and increased uptake into dental plaque are attained by the development of stable mouthrinses adjusted to a pH in the range of 4.0 to 5.6, preferably about 4.5. The compositions may contain a zinc salt as an optional ingredient. Various types of buffer systems are described.

Oral rinse compositions

Growing community of inventors

Fort Collins, CO, United States of America

Kenneth S Peterson