Maple Ridge Group, LLC

Hour 72

Kenneth Rothaus

Michael Milbocker

The present disclosure generally provides topically applicable insect repelling compositions, and in some embodiments, topically applicable insect repelling and UV protecting compositions. The compositions comprise a polymerization product of a polyol, a diisocyanate and at least one insect-repelling compound. The resulting polymers advantageously bond superficially to skin or hair, thereby localizing repellents and preventing systemic absorption. While not being bound by theory, it is believed that the localization of repellents to the surface of the skin renders them safer, wherein such repellents are not vaporized and do not have a disagreeable odor. The repellents advantageously interact with tactile insect activity, thereby preventing parasitic activity, such as drawing blood or the communication of pathogens.

Tissue bonding insect repellent

Compositions and methods thereof, for preventing or minimizing skin penetration and that promote surface-layer fixation of dermatological molecules in a human body are disclosed. The molecules of the present invention and compositions containing said molecules comprise a tissue-reactive part, an amphiphilic part, a light-functional part and optionally a detachment mechanism for releasing said tissue-reactive part from said light-functional part. The methods include ways of combining the tissue-reactive part, amphiphilic part, light-functional part and optionally synthesizing a detachment mechanism therein. The parts when combined form molecular structures possessing novel photobiological persistence and efficacy.

Topical with static photobiological functionality

A molecule for stabilizing a bioactive chemical group capable of releasing nitric oxide in vivo is described. The molecule possesses multi-functionality, enabling the delivery of multiple nitric oxide precursors on a single molecule. In some embodiments, a tissue or prosthetic bonding group is attached to one of the functional arms of the molecule making the molecule of the present invention localizing to tissue or an implant.

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New York, NY, United States of America

Kenneth Rothaus