May & Baker, Ltd.

Kenneth Robert Wooldridge

Barbara Joyce Broughton

Stuart Malcolm Marshall

David Lord Pain

Bryan John Large

Brian W Sharp

Dennis Warburton

Raymond Barry Williams

Berkeley Basil

Benzophenone derivatives of the formula: ##STR1## wherein R.sup.1 is isopropyl, t-butyl or 2-phenylethyl, R.sup.2 is methyl or chlorine, n is 1 or 2 and m is 0, 1 or 2, are new compounds possessing pharmacological properties especially indicative of utility in the treatment of migraine.

Benzophenone derivatives

8-Azapurin-6-ones substituted in the 2-position by a phenyl group carrying in a meta-position a sulphamoyl substituent, and also a hydroxy, alkoxy or alkylthio substituent para with respect to the said sulphamoyl grouping, and pharmaceutically acceptable salts thereof, possess pharmacological properties useful in the treatment of allergic respiratory disorders, for example allergic bronchial asthma.

Azapurinones

The invention provides certain novel 8-azapurin-6-one derivatives substituted in the 2-position by a substituted phenyl group, preferably carrying an alkoxy in the 2-position, which possess valuable pharmacological properties especially in the treatment of respiratory disorders manifested by the interaction of tissue-fixed antibodies with specific antigens.

8-Azapurin-6-ones substituted in the 2-position by an unsubstituted or substituted phenyl or naphthyl group, or by an alkenyl or alkynyl group, a cycloalkyl group, an alkyl group contaning 2 to 10 carbon atoms, or an alkyl group containing 1 to 10 carbon atoms carrying one or more substitutents selected from halogen atoms and hydroxy, cycloalkyl, alkoxy, phenyl and substituted phenyl groups, and pharmaceutically acceptable salts thereof, possess pharmacological properties useful, for example, in the treatment of allergic bronchial asthma.

Pharmaceutical compositions comprising azapurinones useful in treating

Compounds of the formula: ##SPC1## Wherein R.sup.1 represents hydrogen, methyl, ethyl, n-propyl, iso-propyl, n-butyl, iso-butyl or sec-butyl, R.sup.2 represents hydrogen or alkyl of 1 through 4 carbon atoms or cycloalkyl of 3 or 4 carbon atoms, and R.sup.3 represents hydrogen, methyl or ethyl, all of which are novel except for three compounds, have been found to be of use in the prevention of coccidiosis in chickens.

Growing community of inventors

Brentwood, United Kingdom

Kenneth Robert Wooldridge