The Procter Gamble Company

Kenneth Robert Wehmeyer

Rohan Lalith Wimalasena

Karl Shiqing Wei

Qing Stella

Cynthia Ann Garza

Gina Marie Fadayel

Dean Larry DuVal

James Robert Schwartz

Jonathan Robert Cetti

Raphael Warren

Charles Carson Bascom

Christopher Dean Putman

David Burton Moore

Miranda Aref Farage

Kevin John Mills

Karen Marie Osorio

Feng Wang

Lijuan Li

Kathleen Marie Kerr

Roy Lee Dobson

Raymond Alan Grant

Angela Marie Fieno

Benjamin F Floyd

Jay Patrick Tiesman

Murray A Friedman

Patricia West Doyle

Thomas Massey Burt

Steven P Sirko

Peter Joseph Stoffolano

Angela Fieno

Rohan Wimalasena

Susan Jeane Biehle

Richard Duffy Farris

Raymond Grant

In various embodiments, provided are methods for selecting and formulating compositions for treating and maintaining the quality of skin in a select population, wherein a composition is selected for use in a personal care product based on its demonstrated biological effect to improve skin quality in the population as evidenced by one or more biomarker changes that correlate with improvement as evidenced by one or more objective measurements of skin health in the population.

Biomarker-based methods for formulating compositions that improve skin quality and reduce the visible signs of aging in skin for individuals in a selected population

An array of methods for assessing vaginal atrophy are disclosed. The methods may be used alone or in combination with a treatment or as part of a kit.

Methods for assessing vaginal atrophy

In various embodiments, provided are methods for selecting and formulating compositions for treating and maintaining the quality of skin, wherein a composition is selected for use in a personal care product based on its demonstrated biological effect to improve skin quality as evidenced by one or more biomarker changes that correlate with improvement as evidenced by one or more objective measurements of skin health.

Biomarker-based methods for identifying and formulating compositions that improve skin quality and reduce the visible signs of aging in skin

A method for measuring of histamine in an epidermis comprising applying an adhesive article to an epithelium of a mammal; allowing for adherence of epithelial cells to the adhesive article; removing the adhesive article from the epithelium of the mammal; preparing the adhesive article using standard laboratory methods for extraction; extracting histamine from the epithelial cells adhered to said adhesive article; measuring histamine from the epithelial cells adhered to said adhesive article; determining the amount of histamine in the epithelial cells as compared to a baseline sample. Further, a method of objectively measuring the perception of itch in mammals and wherein there is a reduction in histamine from a baseline level which is directly proportional to a reduction in an itch perception.

Noninvasive method for measuring histamine from skin as an objective measurement of itch

The subject invention involves compositions comprising 4-(3,5-bis(1,1-dimethylethyl-4-hydroxyphenyl)-4-oxobutanamide, or 4-(3,5-bis-(1,1-dimethylethyl)-4-hydroxyphenyl)-4-oxobutanoic acid and pharmaceutically-acceptable salts thereof, and a pharmaceutically-acceptable carrier. The subject invention also involves methods for treating diseases characterized by inflammation and/or pain, such as rheumatoid arthritis and osteoarthritis, in humans or lower animals by administration of a safe and effective amount of this compound to the human or lower animal in need of such treatment.

4(3,5-bis(1,1-dimethylethyl-4-hydroxyphenyl)-4-oxobutanamide compound

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Cincinnati, OH, United States of America

Kenneth Robert Wehmeyer