Pfizer Corporation

Kenneth Richardson

Kelvin Cooper

Peter J Whittle

Michael J Fray

Geoffrey E Gymer

John Steele

Peter E Cross

Roger P Dickinson

Andrew Simon Bell

Robert J Bass

Rhona M Plews

Stephen J Ray

Peter Thomas Stephenson

James Robert Wright

Subramaniyan Narayanaswami

Melvin Cooper

William A Million

Alan Patrick Marchington

Kevin Cooper

Michael J Parry

Triazole antifungal agents

The invention provides antifungal compounds of the formula: ##STR1## and pharmaceutical salts thereof, wherein

The invention provides antifungal agents of the formula: ##STR1## and their pharmaceutically acceptable salts, wherein

The invention provides antifungal agents of the formula: ##STR1## and their pharmaceutically acceptable salts, wherein R is phenyl optionally substituted by 1 to 3 substituents each independently selected from halo and CF.sub.3 ;

Intermediates useful in the synthesis of dihydropyridine platelet activating factor antagonists of the formula ##STR1## where R is phenyl or substituted phenyl; R.sup.3 is lower alkyl; Y is 1,4-phenylene and X is 2-alkylimidazopyridyl.

Alkyl 2-benzylidene-4-(2-alkylimidazopyrid-1-yl) benzoylacetate esters

Platelet activating factor antagonists of formula (I): ##STR1## wherein R is phenyl or phenyl substituted by one or more substituents selected from nitro, halo, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, aryl(C.sub.1 -C.sub.4)alkoxy, fluoro(C.sub.1 -C.sub.4)alkoxy, C.sub.1 -C.sub.4 alkylthio, C.sub.1 -C.sub.4 alkylsulphonyl, hydroxy, trifluoromethyl and cyano, or is phenyl fused to a dioxole ring;

Platelet activating factor antagonists

Intermediates useful in the synthesis of dihydropyridine platelet activating factor antagonists of the formula ##STR1## where R is phenyl or substituted phenyl; R.sup.3 is lower alkyl; Y is 1,4-phenylene and X is a benzimidazol-1-yl.

Alkyl 2-benzylidene-4-(benzimidazol-1-yl) benzoylacetate esters as

Compounds of the formula ##STR1## or a pharmaceutically or agriculturally acceptable acid addition salt thereof, wherein R is 5-chloro-2-pyridyl, or phenyl optionally substituted by one to three substituents, each independently selected from F, Cl, Br, I, CF.sub.3, C.sub.1 -C.sub.4 alkyl and C.sub.1 -C.sub.4 alkoxy; R.sup.1 is CN, CSNH.sub.2 or CONR.sup.2 R.sup.3 where either

3-aryl-3-hydroxy-4-(1H-1,2,4-triazol-1-yl)butyramide and derivatives as

The invention provides triazole antifungal compounds of the formula: ##STR1## wherein R is either (a) a phenyl group optionally substituted with 1 to 3 substituents, each selected independently from halo and CF.sub.3 ; or

Triazole antifungal agents of the formula ##STR1## where R is 5-chloropyrid-2-yl or phenyl optionally substituted by 1 to 3 substituents each independently selected from F, Cl, Br, I, CF.sub.3, C.sub.1 -C.sub.4 alkyl and C.sub.1 -C.sub.4 alkoxy; and R.sup.1 is H or CH.sub.3 ; and their O-esters, O-ethers and pharmaceutically and agriculturally acceptable salts. The compounds are useful as human and agricultural antifungal agents.

Antifungal 1,3-bis (1H-1,2,4-triazol-1-yl)-2-aryl butan-2-ols and

Compounds of the formula ##STR1## where R.sup.1 is lower alkyl, R.sup.2 is chlorophenyl, Y is alkylene, X is heterocyclic and Z is a fused ring are useful as antiinflammatory and antiallergy agents.

Certain oxo-pyrrolo 1,4-dihydropyridines as antiallergy and

The invention provides compounds of the formula ##STR1## and pharmaceutically acceptable salts thereof, wherein R is phenyl substituted by halo;

1,4-dihydropyridine derivatives

Triazoles of the formula ##STR1## where R is phenyl optionally substituted by 1 to 3 substituents each independently selected from F, Cl, Br, I, CF.sub.3, C.sub.1 -C.sub.4 alkyl and C.sub.1 -C.sub.4 alkoxy, or R is 5-chloro-pyrid-2-yl; and R.sup.1 is H, CH.sub.3 or F; and their pharmaceutically and agriculturally acceptable salts. The compounds are useful as human and agricultural fungicides.

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Canterbury, United Kingdom

Kenneth Richardson