Wyeth

Other

Millennium Pharmaceuticals Limited

Kenneth Rhodes

Huai-Ping Ling

Maria Betty

Wenqian An

Kathleen H Young

Wengian An

Nancy Rhodes

The invention provides isolated nucleic acids molecules, designated PCIP nucleic acid molecules, which encode proteins that bind potassium channels and modulate potassium channel mediated activities. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PCIP nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a PCIP gene has been introduced or disrupted. The invention still further provides isolated PCIP proteins, fusion proteins, antigenic peptides and anti-PCIP antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

Nucleic acids encoding potassium channel interactors

Human 9q polypeptides method

The invention provides methods for identifying compounds suitable for treating a cardiovascular disorder, as well as methods for treating a cardiovascular disorder. The invention also provides methods for determining if a subject is at risk for a cardiovascular disorder.

Methods for treating cardiovascular disorders

Potassium channel interactors and uses therefor

Methods and compositions for identifying compounds which disrupt the functional interaction of an intracellular receptor region of an &#x3b1;-subunit of a voltage-gated ion channel and an amino-terminal inactivation region of an ion channel protein are disclosed. Compounds that disrupt the functional or binding interaction of these two regions have significant modulatory effects on ion channel activity, and thus are likely to be useful for treating and/or preventing a wide variety of diseases and pathological conditions associated with ion channel dysfunction. Such conditions include, for example, neurological disorders, cardiac diseases, metabolic diseases, tumor-driven diseases, and autoimmune diseases.

Methods for identifying modulators of N-type ion channel inactivation

Potassium channel interacting polypeptides and uses thereof

Nucleic acid molecules encoding potassium channel interactors and uses therefor

A combination cigarette pack and lighter holder of the type having a base member insertable within a top member is provided. The combination cigarette pack and lighter holder comprises: a base member having a first section defining a cigarette compartment adapted for disposing a cigarette pack therein and a second section defining a lighter compartment adapted for disposing a cigarette lighter therein, the second section being substantially centered along the vertical axis of the front wall of the first section and extending outwardly therefrom; and a top member adapted for removably inserting the base section therein, in a manner such that the cigarette pack and lighter are contained within the combination cigarette pack and lighter holder.

Combination cigarette pack and lighter holder

Growing community of inventors

Neshanic Station, NJ, United States of America

Kenneth Rhodes