Battelle Memorial Institute

Kenneth R Sims, Jr

Cherry Gupta

Danielle J Huk

Anthony David Duong

Stephanie Kute

Jacob Lilly

Andrea D Mccue

Mike Koeris

Jacqueline Grible

Michael Wagner

Michael Riedl

Julianne Np Smith

Joanna L Hoy

Shannon D Miller

Caleb T Hillrich

Emma K Schmitz

Zachary R Shank

Ashlee J Colbert

The disclosure relates to block copolymer nanoparticles for in vivo therapeutic delivery, and methods therefor. More particularly, the invention relates to polymer nanoparticles, such as reversible addition-fragmentation chain transfer (RAFT) polymer compositions, for delivering nucleotides that encode polypeptides.

Polymer nanoparticle compositions for in vivo expression of polypeptides

The invention relates to polymer nanoparticle and DNA nanostructure delivery compositions for non-viral delivery, and methods therefor. More particularly, the invention relates to polymer nanoparticle delivery compositions, such as reversible addition-fragmentation chain transfer (RAFT) polymer compositions, and DNA nanostructure delivery compositions, such as DNA origami compositions, for the delivery of more than one payload, or for the delivery of a nucleic acid construct payload of 3 kB or more, and methods therefor.

Polymer nanoparticle and DNA nanostructure compositions and methods for non-viral delivery

The disclosure relates to barcoded polymer nanoparticles for in vivo screening and for in vivo therapeutic delivery, and methods therefor. More particularly, the invention relates to polymer nanoparticles, such as reversible addition-fragmentation chain transfer (RAFT) polymer compositions, associated with polynucleotide barcodes, for therapeutic delivery, and for high throughput in vivo screening of drug delivery nanoparticles.

Rapid design, build, test, and learn technologies for identifying and using non-viral carriers

Growing community of inventors

Delaware, OH, United States of America

Kenneth R Sims, Jr