Boston University

The Brigham and Women's Hospital, Inc.

Kenneth R Lutchen

Bela Suki

Edward P Ingenito

Andrew C Jackson

David W Kaczka

A system and method for ventilating a lung in a living being by varying the peak inspiratory pressure. The peak inspiratory pressure may deviate about a mean that is chosen to correspond with a knee in a pressure-volume curve of the lung.

Variable peak pressure ventilation method and system

A novel ventilator waveform having an enhanced inspiratory flow pattern is ideally suited for determining an effective &ldquo;inspiratory impedance&rdquo; in ventilator-dependent patients, and/or patients with severe obstruction resulting in expiratory flow-limitation. This waveform is referred to herein as the &ldquo;Enhanced Ventilator Waveform&rdquo; (EVW). The EVW maintains ventilatory support while simultaneously providing an accurate and sensible assessment of the mechanical status of the lungs or total respiratory system. The EVW technique of the present invention ensures that normal (tidal) volume levels are delivered during each inspiration, and that expiration remains passive. Furthermore, accurate estimation of lung resistance and elastance is established for several frequencies surrounding the primary ventilator breathing rate. From the resistance and elastance data, the mean level and structural distribution of airway versus tissue constriction conditions in the lung can be inferred. Additionally, the distribution of delivered gas is more uniform (i.e, more beneficial to the patient) with the EVW, as compared to conventional waveforms.

Enhanced ventilation waveform device

An infant respiratory impedance measuring apparatus and method using forced oscillations is disclosed. In order to account for the effects of the mask, a shunt compliance is placed in parallel with the components representing the impedance of the infant.

Growing community of inventors

Framingham, MA, United States of America

Kenneth R Lutchen