Other

Johns Hopkins University

Gilead Sciences, Inc.

Cytochroma Inc.

Kenneth R Crawford

Gary H Posner

Qiang Wang

Jay A White

Richard P Polniaszek

Byung-Chul Suh

Eric Dowdy

Hong Woon Yang

Glenville Jones

Arnold J Gutierrez

Richard Hung Chiu Yu

Uttam Saha

Heung Bae Jeon

HeungBae Jeon

Mark Hatcher

Steven M Silverman

Jae-Kyoo Lee

Gyoonhee Han

Jae Kyoo Lee

Richard Hung Yu

Arnold Gutierrez

Fly swatter container

A process for the synthesis of bisfuran intermediates useful for preparing antiviral HIV protease inhibitor compounds is hereby disclosed.

Process for preparation of HIV protease inhibitors

The present invention provides novel D-ring and side-chain analogs of 1&#x3b1;,25-dihydroxyvitamin D, compositions comprising these compounds and methods of using these compounds as selective inhibitors of CYP24. In particular, the compounds of the invention are useful for treating diseases which benefit from a modulation of the levels of 1&#x3b1;,25-dihydroxyvitamin D, for example, cell-proliferative disorders.

[object Object]

The present invention provides novel C24-sulfone analogs of 1&#x3b1;,25-dihydroxy vitamin D, compositions comprising these compounds and methods of using these compounds as selective inhibitors of CYP24. In particular, the compounds of the invention are useful for treating diseases which benefit from a modulation of the levels of 1&#x3b1;,25-dihydroxy vitamin D, for example, cell-proliferative disorders.

Novel sulfur-containing analogs of 1&agr;,25-dihydroxy vitamin D are provided. These analogs are synthesized in a convergent manner by joining A-ring and C,D ring fragments. Each analog with 1&agr;,3&bgr;-substituent stereochemistry shows a pharmacologically desirable combination of high antiproliferative and high transcriptional activities in vitro and also low calcemic activity in vivo.

Non-calcemic, antiproliferative, transcriptionally active sulfur-containing analogs of 1&agr;, 25-dihydroxy vitamin D3

A new display carrier container for displaying a message, such as an advertisement. The inventive device includes a generally transparent tubular body having inner and outer surfaces and a pair of opposite ends. The inner surface of the body defines a lumen. Each end of the body has a opening into the lumen of the body. A pair of end caps are coupled to the ends of the body such that they close the openings of the ends of the body. One of the ends of the body has a slot therein. The slot is located between the inner and outer surfaces of the body and extends from the one end towards the other of the ends of the body. The slot is adapted for receiving a sheet therein.

Display carrier container

A folding knife holder and method, whereby a folding knife can be safely carried in an elongate knife holder, comprising a housing member that has an elongate recess defined by a base surface, side surfaces and end surfaces, and sized and shaped to receive the knife in an orientation that is substantially parallel to the base surface, with the spine of the knife laying against the base. The margin of the walls of the housing member define an elongate orifice opening into the recess. The orifice is partially occluded at one end by a strike member. The strike member has a gap, wider than the knife blade. When the back of the knife blade is grasped and pulled in an outward direction, the knife blade will pass through the gap in the strike member and the strike member will blockingly engage the butt of the knife handle, thereby allowing the knife blade to be pivotably rotated into an open position.

Folding knife holder and method for one-handed opening of a folding knife

Growing community of inventors

San Mateo, CA, United States of America

Kenneth R Crawford