Terumo Kabushiki Kaisha

Allergan Holdings France S.a.s.

Cierra, Inc.

Tautona Group Research and Development Company, L.l.c.

On Demand Therapeutics, Inc.

Other

Allergan, Inc.

Autonomic Technologies, Inc.

Neodyne Biosciences, Inc.

Tautona Group LP

Microchips, Inc.

Kenneth N Horne

Mark E Deem

William W Malecki

Dan Francis

Jose D Alejandro

Hanson Gifford

Geoffrey C Gurtner

Hanson S Gifford, Iii

Michael H Rosenthal

Jayakumar Rajadas

Joseph Rimsa

Erik T Engelson

Uday N Kumar

Miriam H Taimisto

Dominique Filloux

Christopher Scott Jones

John T Santini, Jr

John Anthony Scholl

Brian J Domecus

Benjamin D Pless

Luke W Clauson

Anthony V Caparso

Darin Charles Gittings

Jasper Jackson

Andrew I Poutiatine

Matthew B Newell

Reinhold H Dauskardt

Jonathan Robert Coppeta

Michael T Longaker

Vivek Shenoy

Keiichiro Ichiryu

John A Zepeda

Doug Sutton

Bankim H Mehta

William R Beasley

Sergio Salinas

Paul G Yock

Cynthia L Stevenson

Kemal Levi

Andy Uchida

Tor C Krog

Michael T Cao

Gregory J R Spooner

Greg J Spooner

Manuel A Cardona Pamplona

Hanson S Gifford

Drew Hoffmann

Venkata Vegesna

Gordon Saul

Naveed Shams

Kellie S Fletcher

Lucia Kim

Jose Alegandro

Jeff Prior

Rene Rodriguez

Melanie Harris

Kin Chan

Hanson S Iii Gifford

Nowell Solish

Tony Gipson

John T Santini

Naveen Jayakumar

Sara Fermanian

Gregory Spooner

The methods, procedures, kits, and devices described herein assist with the healing process of tissue that was previously or simultaneously treated for a therapeutic or cosmetic effect. The methods, procedures, kits, and devices described herein can also provide temporary simulated results of a cosmetic procedure to allow for visual assessment to select the type of procedure or for treatment planning in advance of the surgical procedure.

Devices and methods for skin tightening

The present invention provides threads of hyaluronic acid, and/or derivatives thereof, methods of making thereof and uses thereof, for example, in aesthetic applications (e.g., dermal fillers), surgery (sutures), drug delivery, etc.

Threads of hyaluronic acid and/or derivatives thereof, methods of making thereof and uses thereof

A substance delivery device that includes a hypodermic needle with a tube for receiving and containing a volume of a substance. The substance delivery device includes a rod, a portion of which is of a size and shape to fit within the tube of the hypodermic needle. The rod can be displaced into and within the tube to contact and apply a force to a volume of substance contained within the tube to cause, at least in part, the volume of substance to be discharged out of the tube. The substance delivery device includes a rod displacement mechanism that applies a force to the rod to cause the rod to be displaced into and within the tube. The substance delivery device also includes a needle retraction mechanism that is configured to apply a force to the hypodermic needle to cause the hypodermic needle to retract from within a patient.

Substance delivery device

Apparatus and methods for nipple and breast formation are described where devices precondition or expand a target nipple tissue to reduce the pressure exerted by the skin on an eventual implant. Generally, the apparatus comprises a mold having a contact surface which is cured in conformance with a breast upon which the mold is positionable, the contact surface having an adhesive for securement upon the breast, and the mold defining a cavity along the contact surface which conforms to a size of a nipple to be formed upon the breast and where the cavity further comprises the adhesive for securement to the nipple. A breast enlargement device comprises a cup larger than the target breast and further defines an inner surface which adheres to the breast when contacted.

Apparatus and methods for nipple and breast formation

Provided herewith is a needle for delivering dermal filler thread to a wrinkle in a patient. The needle can also be used to deliver the thread to a patient for the purposes of facial contouring. The needle comprises a coupler for attaching the thread to the needle and also a trocar to ease delivery through the skin.

Needle for delivery of dermal filler threads

Disclosed herein are syringes having temperature modulation capabilities particularly with regard to changing the temperature of the material being ejected from or injected into the syringe and methods of use. In a specific embodiment of this invention, the syringe comprises a phase transition composition which is to be maintained in one phase within the syringe chamber and ejected in a different phase from the syringe.

Syringe with temperature modulation capabilities

Apparatus and methods for nipple and breast formation are described where devices precondition or expand a target nipple tissue to reduce the pressure exerted by the skin on an eventual implant. Generally, the apparatus comprises a mold having a contact surface which is curved in conformance with a breast upon which the mold is positionable, the contact surface having an adhesive for securement upon the breast, and the mold defining a cavity along the contact surface which conforms to a size of a nipple to be formed upon the breast and where the cavity further comprises the adhesive for securement to the nipple. A breast enlargement device comprises a cup larger than the target breast and further defines an inner surface which adheres to the breast when contacted.

Methods and apparatus for delivering therapy from an implanted neurostimulator to a patient are provided. One feature is an external controller that acts as a gateway for therapy. The external controller can be a handheld controller that communicates wirelessly with the implanted neurostimulator. In some embodiments, the controller communicates with a database to determine a therapy approval status of the neurostimulator. Therapy can be approved by a physician prescription, or by prepayment, for example. In some embodiments, the neurostimulator is deactivated when no approved therapies remain.

Approval per use implanted neurostimulator

Apparatus and methods for nipple formation via collapsible devices

Threads of Hyaluronic acid and/or derivatives thereof, methods of making thereof and uses thereof

An implantable drug delivery device that uses multiple reservoir elements to contain and release doses of active pharmaceutical ingredients. The device includes a first shell element, which has a first enclosed cavity volume and forms a low-permeability barrier. The first shell element is configured to absorb light irradiation from a laser source, the laser irradiation causing a breach in the first shell element. A first active pharmaceutical ingredient is contained in the first enclosed cavity volume and is released when the first shell element is breached. The device also includes a second shell element, which has a second enclosed cavity volume and also forms a low-permeability barrier. A second active pharmaceutical ingredient is contained in the second enclosed cavity volume. The device also includes an envelope element containing the first and second shell elements.

Low-permeability, laser-activated drug delivery device

The present disclosure relates to methods for visualizing the opening of a drug reservoir of an implantable medical device. In particular, the present disclosure provides methods for observing the release or exposure of contents from a drug reservoir of a medical device placed within the vitreous of an eye of a subject. The methods include implanting a drug delivery device within an anatomy of a subject. The drug device includes a plurality of reservoirs, each loaded with a therapeutic agent and a marker. Furthermore, the drug delivery device comprises a plurality of barrier layers for separating the contents of one of the plurality of reservoirs from the anatomy. The method further includes irradiating at least one of the plurality of barrier layers such that at least one of the plurality of reservoirs is breached, thereby triggering release of the therapeutic agent and the marker from the device. By visually detecting release of the marker into the anatomy, release of the therapeutic agent into the anatomy is verified.

Visual indication of rupture of drug reservoir

Growing community of inventors

San Francisco, CA, United States of America

Kenneth N Horne