Schering Corporation

Kenneth Miller

Nicholas J Murgolo

Barbara Dalie

Stephen Tindall

Hung V Le

Paul J Zavodny

Hanh Nguyen

Humanized monoclonal antibodies against human interleukin-4

Monoclonal antibodies are provided which are specific for human interleukin-4. Also provided are complementary DNAs which encode the heavy and light chain variable regions of such monoclonal antibodies and complementarity determining regions from such DNAs; and kits and methods for detecting, measuring and immunopurifying human interleukin-4, and for blocking the biological activity of human interleukin-4.

Cloning and exprssion of humanized monoclonal antibodies against human

Humanized monoclonal antibodies are provided which are specific for human IL-4 and have properties unexpectedly superior to other, previously available humanized antibodies. Also provided are nucleic acids which encode the heavy and light chain variable regions of such monoclonal antibodies or antigenic fragments thereof; anti-idiotypic antibodies; and methods for detecting, measuring and immunopurifying human IL-4, and for blocking or mimicking the biological activity of human IL-4.

Growing community of inventors

Cranford, NJ, United States of America

Kenneth Miller