Ethicon, Gmbh

Kenneth Michael Keilman

Sasa Andjelic

Dennis D Jamiolkowski

Leo B Kriksunov

Robert J Tannhauser

Gerard H Llanos

Jianguo Jack Zhou

Marc Wisnudel

Nicholas M Popadiuk

Sai Veruva

John J Karl

Joseph Vliet

Sasa Andjeli&cacute;

Oliver S Sosely

Hwason Goddard

The present invention is directed to a length adaptive surgical suture comprising a monofilament or a braid of a plurality of filaments, the suture having an original length when implanted and a second length that is different from the original length within a first twenty-four (24) hour period of time after implantation to accommodate tissue swelling. The present invention is also directed to configurations and combinations that enable length adaptive results.

Adaptive sutures dynamically changing wound holding properties post-implantation

An absorbable hemostatic nonwoven patch utilizes a biocompatible substrate comprised of melt-blown microfibers as webbed sheets that are layered and bonded/entangled in descending density and ascending porosity; the substrate having a high flexibility, strength and porosity that is suitable for coating cross-linkable active molecules and ability for laparoscopic use or trocar deployment, ultimately for functional use as a highly effective hemostat in addressing problematic bleeding during both open and minimally invasive surgical procedures.

Melt blown dressing with gradient density

Novel semi-crystalline, p-dioxanone-rich ABA triblock copolymers of p-dioxanone and epsilon-caprolactone, where 'B' block is a random copolymer of p-dioxanone and epsilon-caprolactone, and absorbable devices for long term medical applications are disclosed. The novel polymer compositions are useful for long term absorbable surgical sutures, and other medical devices.

Segmented, p-Dioxanone-Rich, Poly(p-Dioxanone-co-epsilon-Caprolactone) copolymers for medical applications and devices made therefrom

Novel absorbable, semi-crystalline, polymer blend compositions are disclosed exhibiting enhanced crystallization and nucleation rates. Also disclosed are medical device constructs, such as fibers made from such blends. The blends have a first absorbable polymeric component having a first molecular weight distribution and a second absorbable polymeric component which has an ultrahigh molecular weight distribution. The first and second polymeric components may be the same polymer.

Absorbable polymer blend compositions having enhanced nucleation rates

Novel absorbable monofilament sutures and fibers having unique and improved properties are disclosed including mid-term strength retention post-implantation. Also disclosed is a novel method of manufacturing absorbable monofilament sutures and fibers. The sutures and fibers are extruded from poly(p-dioxanone-co-glycolide) copolymers.

Absorbable poly (p-dioxanone-co-glycolide) monofilament fibers possessing mid-term strength retention post-implantation

The present invention is directed to absorbable, autoclaveable, monofilament fibers prepared from absorbable glycolide-rich polymers, in which the fibers are oriented in the total draw ratio range 4.1 to 5.6&times;, and are annealed at a temperature between about 165&deg; C. and about 185&deg; C.; to brachytherapy seed spacers manufactured from the absorbable, autoclaveable, glycolide-rich polymers, monofilament fibers; and to methods of manufacturing such fibers and brachytherapy seed spacers.

Process of making synthetic absorbable autoclaveable monofilament fibers and brachytherapy seed spacers

We have discovered a process for producing a suture from copolymers of glycolide and .epsilon.-caprolactone comprising the steps of (a) extruding a melted copolymer of a glycolide and .epsilon.-caprolactone resin through an orifice and rapidly quenching the melted copolymer resin to produce a filament; (b) drawing the filament in the range of from about 4.times. to about 7.5.times. to produce a singly drawn filament; (c) drawing the singly drawn filament in the range of form about 1.times. to about 3.times. in a first heated zone being maintained at a temperature in the range of from about 150.degree. F. to about 450.degree. F., to form a doubly drawn filament; (d) shrinking the doubly drawn filament in the range of from about 0.75 percent to about 0.98 percent, in a second heated zone being maintained at a temperature in the range of from about 100.degree. F. to about 400.degree. F., to form a relaxed filament then rack annealing the relaxed filament to form a glycolide/.epsilon.-caprolactone suture.

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Raritan, NJ, United States of America

Kenneth Michael Keilman