Pacific Biosciences of California, Inc.

Kenneth Mark Maxham

John S Eid

Jon M Sorenson

Patrick Marks

Stephen Wilson Turner

David J Holden

Austin B Tomaney

Devon Murphy

Kevin Hester

Kevin Travers

Robin A Emig

Cheryl Heiner

Benjamin A Flusberg

Donald M Gray

Mark Chaisson

Methods, devices, and systems for performing intermittent detection during analytical reactions are provided. Such methods facilitate collection of reaction data from disparate reaction times. Further, such methods are useful for reducing photo-induced damage of one or more reactants in an illuminated analytical reaction at a given reaction time. In preferred embodiments, the reaction mixture is subjected to at least one illuminated and non-illuminated period and allowed to proceed such that the time in which the reaction mixture is illuminated is less than a photo-induced damage threshold period.

Intermittent detection during analytical reactions

Computer implemented methods, and systems performing such methods for processing signal data from analytical operations and systems, and particularly in processing signal data from sequence-by-incorporation processes to identify nucleotide sequences of template nucleic acids and larger nucleic acid molecules, e.g., genomes or fragments thereof.

Methods and processes for calling bases in sequence by incorporation methods

Nucleic acid sequence analysis

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Redwood City, CA, United States of America

Kenneth Mark Maxham