The United States of America, as Represented by the Secretary, Department of Health and Human Services

Harbor Branch Oceanographic Institution, Inc.

Spirogen Limited

Midwest Research Institute

Starks Associates Inc.

Kenneth M Snader

B Rao Vishnuvajjala

Tatsuo Higa

Philip Wilson Howard

David Edwin Thurston

Paul S Liu

Luke Y Hsiao

Gregory Turner

Tsutomu Akama

Stephen John Gregson

Edward A Sausville

Melinda G Hollingshead

B Rao Vishnuvaijala

Disclosed are compounds of Formula I wherein X, Y, R-R, T, T, Z, and p are as described herein; a pharmaceutical composition comprising a compound of Formula I and a carrier; a method of inhibiting growth of a cell, which method comprises administering in an amount effective to inhibit growth a compound of Formula I; a method of treating cancer in a mammal, which method comprises administering in an amount effective to treat cancer a compound of Formula I; a method of treating a viral, parasitic, or bacterial infection of a cell, which method comprises administering in an amount effective to treat a viral, parasitic, or bacterial infection a compound of Formula I; and a method of preparing a compound of Formula I as described herein.

Pyrrolobenzodiazepine derivatives, compositions comprising the same and methods related thereto

Disclosed are compounds of Formula (I) wherein X, Y, Ri-R, T, T, Z, and p are as described herein; a pharmaceutical composition comprising a compound of Formula (I) and a carrier; a method of inhibiting growth of a cell, which method comprises administering in an amount effective to inhibit growth a compound of Formula (I); a method of treating cancer in a mammal, which method comprises administering in an amount effective to treat cancer a compound of Formula (I); a method of treating a viral, parasitic, or bacterial infection of a cell, which method comprises administering in an amount effective to treat a viral, parasitic, or bacterial infection a compound of Formula (I); and a method of preparing a compound of Formula (I) as described herein. 

A compound of formula I: or solvate thereof, wherein n is 1 to 10, and M and M' are independently selected from monovalent pharmaceutically acceptable cations, or together represent a divalent pharmaceutically acceptable cation.

Pyrrolobenzodiazepines

A geldanamycin derivative exhibiting significant preliminary in vivo activity, particularly significant oral in vivo activity, and a method of treating or preventing cancer in a host comprising administering a geldanamycin derivative to a host in an amount sufficient to treat or prevent cancer.

Geldanamycin derivative and method of treating cancer using same

The invention provides an aminoflavone having formula (I), wherein each of R and R is H, COCH &mdash;R , wherein R is amino alkylamino, dialkylamino, or alkyl- or dialkylaminoalkyl, or an &agr;-amino acid residue, provided that at least one of R or R is other than H, and R is H, branched or straight-chain alkyl, hydroxyalkyl, alkanoyloxyalkyl, alkanoyloxy, alkoxy, or alkoxyalkyl, or pharmaceutically acceptable salts thereof. The present invention also provides a pharmaceutical composition comprising an aminoflavone as described above, and a method of inhibiting the growth of a tumor in a host by administering a tumor growth-inhibiting amount of an aminoflavone compound having the formula as described above.

Aminoflavone compounds, compositions, and methods of use thereof

This invention relates to antitumor compositions, and a method for inhibiting, remitting or controlling the growth of tumors or tumor cells utilizing antitumor compositions. More particularly, the antitumor compositions comprise, as active ingredient, an antitumor effective amount of halogenated chamigrenes extracted and derived from red alga and sea hares which diet upon red alga.

Antitumor chamigrene derivatives and their methods of use

This invention relates to antiviral and antitumor compositions, a process for producing the compositions and a method for inhibiting viruses and tumors utilizing the compositions. More particularly, the compositions are cyclohexadienone derivatives which are derived from red alga Desmia hornemanni.

Antiviral and antitumor cyclohexadienone compositions

This invention relates to antiviral compositions, a process for producing the compositions and a method for inhibiting viruses utilizing the compositions. More particularly, the compositions are halogenated chamigrenes extracted from sea hares which diet upon red algae.

Growing community of inventors

Vero Beach, FL, United States of America

Kenneth M Snader