Aventis Pharmaceuticals Inc.

Rhone-Poulenc Rorer Pharmaceuticals Inc.

Rorer Pharmaceutical Corporation

Kenneth M Feld

Richard J Harwood

Wayne M Grim

Joseph R Luber

Cynthia M Ciliberto

Donna M Heren

A dissolution test sample holder for testing topical formulations for dermal and/or transdermal drug delivery is disclosed. The holder has a cylinder tubular body with an end cap removably attached to one end. The end cap has a peripheral wall which frictionally engages the body to hold the end cap in place. A flange extends perpendicularly from the peripheral wall inwardly defining an aperture in the end cap and providing a support surface for a membrane held within the end cap. A ring is positioned within the end cap on the membrane, the membrane being sandwiched between the ring and the support surface. The ring protects the membrane by preventing contact between it and the body and provides a volume for holding the test sample in contact with the membrane.

Dissolution test sample holder

A process for the preparation of a viscosity-stable antacid composition containing an alginic acid salt comprising reacting an antacid material with said salt at elevated temperatures to form a reaction product and recovering said reaction product in stabilized form.

Process for the preparation of a viscosity-stable antacid composition

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Chalfont, PA, United States of America

Kenneth M Feld