United States of America, As Represented by the Secretary of Agriculture

Kenneth M Bischoff

Timothy D Leathers

Neil P Price

Pennapa Manitchotpisit

David M Donovan

Stephen R Hughes

Siqing Liu

Brian J Wilkinson

Dwayne R Roach

Piyum A Khatibi

Compounds, called liamocins from, having the general structure in Formula 1 are disclosed. where Ris either COCHor H; and Ris between two to ten O-linked 3,5-dihydroxydecanoate; and Rcan be a polyol (e.g., L- or D-glycerol, L- or D-threitol, L- or D-erythritol, L- or D-arabitol, L- or D-xylitol, L- or D-lyxitol, L- or D-ribitol, L- or D-allitol, L- or D-altritol, L- or D-mannitol, L- or D-iditol, L- or D-gulitol, L- or D-glucitol (also called sorbitol), L- or D-galactitol (also called dulcitol), and L- or D-talitol), 2-amino-D-mannitol, 2N-acetylamino-D-mannitol, L-rhamnitol, or D-fucitol; except when Ris D-mannitol, Ris not 2 nor 3 O-linked 3,5-dihydroxydecanoate chains. These liamocins described above in addition to D-mannitol liamocin A1, D-mannitol liamocin A2, D-mannitol liamocin B1, and D-mannitol liamocin B2, alone or in combination with each other, can be used to kill certain bacteria and to treat certain bacterial infections.

Oils having antibacterial activity

Novel compounds, called liamocins from, having the general structure in Formula 1 are disclosed. where Ris either COCHor H; and Ris between two to ten O-linked 3,5-dihydroxydecanoate; and Rcan be a polyol (e.g., L- or D-glycerol, L- or D-threitol, L- or D-erythritol, L- or D-arabitol, L- or D-xylitol, L- or D-lyxitol, L- or D-ribitol, L- or D-allitol, L- or D-altritol, L- or D-mannitol, L- or D-iditol, L- or D-gulitol, L- or D-glucitol (also called sorbitol), L- or D-galactitol (also called dulcitol), and L- or D-talitol), 2-amino-D-mannitol, 2N-acetylamino-D-mannitol, L-rhamnitol, or D-fucitol; except when Ris D-mannitol, Ris not 2 nor 3 O-linked 3,5-dihydroxydecanoate chains. These liamocins described above in addition to D-mannitol liamocin A1, D-mannitol liamocin A2, D-mannitol liamocin B1, and D-mannitol liamocin B2, alone or in combination with each other, can be used to kill certain bacteria and to treat certain bacterial infections.

Ethanol losses due to bacterial contamination in fermentation cultures weakens the economics of biofuel production.species are the predominant contaminant. Bacteriophage lytic enzymes are peptidoglycan hydrolases which degrade Gram positive cell walls when exposed externally and are a novel source of antimicrobials. The streptococcal phage &#x3bb;SA2 endolysin construct demonstrated strong lytic activity towards 17 of 22 strains of lactobacilli, staphylococci or streptococci maintaining optimal specific activity under fermentation conditions towardsubstrates.bacteriophage endolysin constructs LysA, LysA2 and LysgaY showed exolytic activity towards &#x2dc;60% of the lactobacilli tested including fourisolates from fuel ethanol fermentations. Presence of ethanol (&#x2266;5%) did not affect lytic activity. Lysins were able to reduce bothandcontaminants in mock fermentations of corn fiber hydrolysates. Recombinant LysA and &#x3bb;Sa2 expressed in the yeastare functional; LysA was shown to reduce lactobacilli in experimentally infected fermentations.

Peptidoglycan hydrolase antimicrobials for eradicating lactobacilli that contaminate and reduce ethanol yields in biofuel fermentation

The present invention relates to an isolatedbacterium, deposited as NRRL B-50314, that secretes a bacteriocin. More specifically, the bacteriocin has antibacterial activity against a range of Gram-positive bacteria, including but not limited to, and otherspecies. Additionally, the bacteriocin has antibacterial activity against methicillin resistant

Growing community of inventors

Morton, IL, United States of America

Kenneth M Bischoff