Eli Lilly and Company

Kenneth Lee Hauser

Alan David Palkowitz

Kenneth Jeff Thrasher

Daniel Jon Sall

Henry U Bryant

Jeffrey A Dodge

Jon Kevin Reel

Brian Stephen Muehl

Winston S Marshall

Timothy Alan Shepherd

Richard L Simon

Kumiko Takeuchi

Mitchell I Steinberg

Celia A Whitesitt

Charles Willis Lugar, Iii

Roger L Robey

James Densmore Copp

Mark Louis Heiman

Charles A Alt

Andrew Michael Ratz

Sherryl L Lifer

William Pfeifer

Gary A Rhodes

K Jeff Thrasher

Donald B Boyd

William Harlan Gritton

William George Trankle

Scott Alan Jones

Yao-Chang Xu

Louis Nickolaus Jungheim

Kennan Joseph Fahey

Larry W Hertel

Jeffrey Daniel Cohen

David E Seyler

Joseph Henry Kennedy

This invention relates to novel compounds which are useful in the modulation of endogenous growth hormone levels in a mammal. The invention further relates to novel intermediates for use in the synthesis of said compounds, as well as novel processes employed in these syntheses. Also included are methods of treating a mammal which include the administration of said compounds.

Growth hormone secretagogues

The present invention provides compounds of formula I and a method of inhibiting the reuptake of serotonin, antagonizing the 5-HT receptor and antagonizing the 5-HT receptor which comprises administering to a subject in need of such treatment an effective amount of a compound of formula I.

Azepine derivatives having effects on serotonin related systems

This application relates to the use as thrombin inhibitors, coagulation inhibitors and thromboembolic disorder agents of diamines of formula I as defined herein. It also provides novel compounds of formula I, processes and intermediates for their preparation, and pharmaceutical formulations comprising the novel compounds of formula I.

Antithrombotic diamines

The invention provides benzothiophene compounds, formulations, and methods of inhibiting bone loss or bone resorption, particularly osteoporosis, and cardiovascular-related pathological conditions, including hyperlipidemia, and other cardiovascular pathologies.

Benzothiophene compounds, intermediates, processes, compositions, and

The present invention provides a compound of formula I: ##STR1## or a pharmaceutically acceptable salt or solvate thereof; having activity as a selective estrogen receptor modulator, pharmaceutical compositions containing a compound of formula I, and methods of using a compound of formula I for treating conditions resulting from estrogen deprivation or the inappropriately high presence of estrogen. Also provided are methods and chemical intermediates for the production of a compound of formula I above.

2-aryl-3-aminoaryloxynaphthy1 compounds, intermediates, compositions and

The instant invention provides a series of naphthyl compounds having an oxygen linker at the 1-position which are useful as selective estrogen receptor modulators.

1-aryloxy-2-arylnaphthyl compounds, intermediates, compositions, and

The invention provides benzothiophene compounds, of formula I, ##STR1## wherein R1, R2, R3, R4 and n are as defined in the specification, formulations, and methods of inhibiting bone loss or bone resorption, particularly osteoporosis, and cardiovascular-related pathological conditions, including hyperlipidemia, and other cardiovascular pathologies.

The present invention provides processes for preparing compounds of formula I ##STR1## and for preparing compounds of formula VII ##STR2## Also provided are processes for preparing compounds of formula VII in addition to intermediates of formula IX ##STR3## wherein R.sup.1' is --OH, or --OR.sup.3, in which R.sup.3 is a hydroxy protecting group; and Z is bromo, iodo, triflate, or --B(OH).sub.2.

Process for preparing 2-substituted benzo �B! Thiophene compounds and

The present invention provides useful intermediates for preparing 2-(substituted phenyl)benzothiophenes compounds said intermediates having the structure ##STR1## wherein R.sup.1 ' is --OH, or --OR.sup.3, in which R.sup.3 is a hydroxy protecting group; and

Process for preparing 2-substituted benzo�B!thiophene compounds and

The present invention provides processes for preparing 2-substituted benzo[b]thiophene compounds, some of which are useful as intermediates for preparing pharmaceutically-active compounds and others which are useful, inter alia, for the treatment of osteoporosis in postmenopausal women.

Process for preparing 2-substituted benzo[b]thiophene compounds and

This invention provides novel phenyl and heterocyclic derivatives, their pharmaceutical formulations and their methods of use for antagonizing angiotensin II receptors in mammals.

Angiotensin II antagonists

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Greencastle, IN, United States of America

Kenneth Lee Hauser