Hawaii Biotechnology Group, Inc.

Kenneth Koo

W Dorsey Stuart

John M Ivy

Neurospora crassa transformations are employed for production of heterologous proteins, where DNA constructs are prepared using a foreign gene under transcriptional and translational regulatory regions functional in Neurospora. A functional signal sequence is provided for secretion of the heterologous gene product. An auxotrophic Neurospora host is employed and transformed by the combination of the subject construct and a complementing gene. The resulting transformants provide for efficient secretion of the heterologous product.

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Encino, CA, United States of America

Kenneth Koo