De Novo Pharmaceuticals Limited

Kenneth Keavey

Raymond Paul Beckett

Paul Gane

Barry Porter

Lydia Saroglou

Henriette Willems

Jac Wijkmans

Compounds of formula (I) and (IA) have antibacterial or antiprotozoal activity: formula (1) formula (2) wherein: Z represents a radical of formula N(OH)CH(&#x2550;O) or of formula C(&#x2550;O)NH(OH); Rrepresents hydrogen, methyl or trifluoromethyl, or, except when Z is a radical of formula N(OH)CH(&#x2550;O), a hydroxy or amino group; Rrepresents a radical of formula R&#x2014;(X)-(ALK)- wherein Rrepresents hydrogen, or an optionally substituted c-Calkyl, C-Calkenyl, C-Calkynyl, cycloalkyl, aryl, or heterocyclyl group, ALK represents a straight or branched divalent C-Calkylene, C-C6 ?alkenylene, or C-Calkynylene radical, and may be interrupted by one or more non-adjacent NH&#x2014;, &#x2014;O&#x2014; or S&#x2014; linkages, X represents NH&#x2014;, &#x2014;O&#x2014; or S&#x2014;, and m and n are independently 0 or 1; Rrepresents hydrogen, C-Calkyl, or benzyl; and Ris as defined in the specification.

Antimicrobial agents

Compounds of formula (I) are antibacterial agents: wherein: Z is &#x2014;N(OH)CH(&#x2550;O) or &#x2014;C(&#x2550;O)NH(OH); Rrepresents hydrogen, methyl or trifluoromethyl or, except when Z is a radical of formula &#x2014;N(OH)CH(&#x2550;O), a hydroxy, halo or amino group; R, Rand Rindependently represents hydrogen or a group R&#x2014;(D)&#x2014;(ALK)&#x2014; wherein R, D, n, m and ALK are as defined in the claims; or Rand Rtaken together with the nitrogen atom to which they are attached form an optionally substituted monocyclic heterocyclic ring containing from 5 to 7 ring atoms, one of which is the nitrogen atom to which Rand Rare attached and the remaining ring atoms being selected from compatible combinations of carbon, oxygen, sulfur and nitrogen 

Bacterial enzyme inhibitors

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Oxford, United Kingdom

Kenneth Keavey