The University of Mississippi

Kenneth Joseph Sufka

Mahmoud Ahmed ElSohly

Waseem Gul

Soumyajit Majumdar

Mohammad Khalid Ashfaq

Hannah Marie Harris

Mahmoud A Elsohly

Biologically active cannabidiol analogs comprising a compound of the formula wherein one of Ror Ror both is/are the residue of a moiety formed by the reaction of an amino group of the amino acid ester of Ror Ror both with a dicarboxylic acid or a dicarboxylic acid derivative and the other Ror R(in the case of the mono) is the residue of a dicarboxylic acid or dicarboxylic acid derivative or Hydrogen (H), (i.e. underivatized), and salts thereof. These CBD analogs are be useful in pain management in oncology and other clinical settings in which neuropathy is presented. Furthermore, these CBD-analogs are useful in blocking the addictive properties of opiates.

Biologically active cannabidiol analogs

This invention relates generally to animal models of anxiety and depression. Specifically, this invention relates to an in vivo high utility, high-throughput model for screening anxiolytic/antidepressant drugs in fowl chicks with stress vulnerability. This new animal model utilizes an inexpensive avian model, measures spontaneous behaviors in very young animals, and is capable of detecting and/or differentiating a compound's anxiolytic and/or antidepressant effects. This new animal model is especially useful in detecting and/or differentiating a compound's anxiolytic and/or antidepressant effects in treatment-resistant subjects. Animal costs are less than 10% of rodent costs and the assay can be run in a high-throughput mode.

Animal model of anxiety and depression

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Oxford, MS, United States of America

Kenneth Joseph Sufka