University of California

Kenneth John Shelly

Marion Frederick Hawthorne

Debra Arliene Feakes

Debra Arlene Feaks

Boron neutron capture therapy can be used to destroy tumors. This treatment modality is enhanced by delivering compounds to the tumor site where the compounds have high concentrations of boron, the boron compounds being encapsulated in the bilayer of a liposome or in the bilayer as well as the internal space of the liposomes. Preferred compounds, include carborane units with multiple boron atoms within the carborane cage structure. Liposomes with increased tumor specificity may also be used.

Methods for boron delivery to mammalian tissue

Boron neutron capture therapy can utilize X,B,H,L where X is an alkali metal, y is 1 to 4, and L is a two electron donor such as NH,, and Na,B,H,NCO, among others. These borane salts may be used free or encapsulated in liposomes. Liposomes may also have embedded within their bilayers carboranes to increase the amount of delivered,B and/or to increase the tumor specificity of the liposome.

Compositions for boron delivery to mammalian tissue

Boron neutron capture therapy can utilize X.sub.y B.sub.20 H.sub.17 L where X is an alkali metal, y is 1 to 4, and L is a two electron donor such as NH.sub.3, and Na.sub.2 B.sub.10 H.sub.9 NCO, among others. These borane salts may be used free or encapsulated in liposomes. Liposomes may have embedded within their bilayers carboranes to increase the amount of delivered .sup.10 B and/or to increase the tumor specificity of the liposome.

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Los Angeles, CA, United States of America

Kenneth John Shelly