Bristol-myers Squibb Compnay

Kenneth J Wilcox

Murray A Kaplan

Joseph B Bogardus

Robert K Perrone

Platinum complexes are disclosed in which the formula is ##STR1## wherein A and B are each independently ammine or monodentate amine, or A and B taken together represent a bidentate amine, and A and B are coordinated to the platinum atom through their nitrogen atom; X and Y are each independently halogen; R' is C.sub.1 -C.sub.20 alkanoyl, aroyl, heteroaroyl, or a group selected from the group consisting of ##STR2## wherein u' is an integer from 1 to 5; and R' is hydrogen with the proviso that A, B, X, and Y are structually equatorial substituents with respect to OR'--Pt--OR'. These platinum complexes show antitumor activity with relatively lower kidney or bone marrow toxicity.

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Syracuse, NY, United States of America

Kenneth J Wilcox