Usgi Medical, Inc.

Medtronic Ardian Luxembourg S.a.r.l.

Abbott Laboratories Vascular Enterprises Limited

Other

Edwards Lifesciences Ag

Sadra Medical, Inc.

Boston Scientific Scimed, Inc.

Amendia, Inc.

Baxano, Inc.

Corporos Inc.

Medtronic Ireland Manufacturing Unlimited Company

Kenneth J Michlitsch

Vahid Saadat

Benjamin J Clark

Andrew H Wu

Richard Christian Ewers

Chris A Rothe

Gerd Seibold

Ib Erling Joergensen

Hanson Gifford

Mark E Deem

Cang C Lam

Nicolas Zadno

Bodo Quint

Stevan Nielsen

Denise Marie Zarins

Randolf Von Oepen

Amr Salahieh

Dwight P Morejohn

Tom Saul

Hans F Valencia

Ulrich R Haug

Robert Adam Geshlider

Rodney A Brenneman

Jan Otto Solem

Denise M Demarais

Erik Thai

Eugene G Chen

Jane P Bearinger

John E Ashley

Jeffery Lee Bleich

Mark S Leung

Tracy D Maahs

Jeffrey Alan Hubbell

Alexander K Khairkhahan

Brian D Brandt

Tommy Conzelmann

Suk-Woo Ha

Karl-Ludwig Eckert

Robert A Vaughan

Per-Ola Kimblad

Eugene C Chen

William R George

Scott E Castanon

Alex Khairkhahan

TOm Saul

Per Ola Kimblad

Eugene Joseph Lee

Yaakov Shmuel Weinstein

Rich C Ewers

Daniel J Keating

Martina Bremser

Bodo Stefan Josef Quint

Rodney C Brenneman

Cang C Laduca

John Paul Sam

Matthew P Michlitsch

Steven D Eppinger

Sean Padgett

Darren Soetantyo

Michael D Rees

Shaun Meredith

Mark Deem

Benjamin C Clark

Jan Otto Solem Solem

The present invention provides apparatus for endovascularly replacing a patient's heart valve. The apparatus includes a replacement valve and an expandable anchor configured for endovascular delivery to a vicinity of the patient's heart valve. In some embodiments, the replacement valve is adapted to wrap about the anchor, for example, by everting during endovascular deployment. In some embodiments, the replacement valve is not connected to expandable portions of the anchor. In some embodiments, the anchor is configured for active foreshortening during endovascular deployment. In some embodiments, the anchor includes expandable lip and skirt regions for engaging the patient's heart valve during deployment. In some embodiments, the anchor comprises a braid fabricated from a single strand of wire. In some embodiments, the apparatus includes a lock configured to maintain anchor expansion.

Everting heart valve

Methods and apparatus are provided for non-continuous circumferential treatment of a body lumen. Apparatus may be positioned within a body lumen of a patient and may deliver energy at a first lengthwise and angular position to create a less-than-full circumferential treatment zone at the first position. The apparatus also may deliver energy at one or more additional lengthwise and angular positions within the body lumen to create less-than-full circumferential treatment zone(s) at the one or more additional positions that are offset lengthwise and angularly from the first treatment zone. Superimposition of the first treatment zone and the one or more additional treatment zones defines a non-continuous circumferential treatment zone without formation of a continuous circumferential lesion. Various embodiments of methods and apparatus for achieving such non-continuous circumferential treatment are provided.

Methods and apparatus for performing a non-continuous circumferential treatment of a body lumen

Balloon catheter apparatuses for renal denervation

Balloon catheter apparatus for renal neuromodulation

The present invention provides methods and apparatus for endovascularly replacing a patient's heart valve. The apparatus includes a replacement valve and an expandable anchor configured for endovascular delivery to a vicinity of the patient's heart valve. In some embodiments, the replacement valve is adapted to wrap about the anchor, for example, by everting during endovascular deployment. In some embodiments, the replacement valve is not connected to expandable portions of the anchor. In some embodiments, the anchor is configured for active foreshortening during endovascular deployment. In some embodiments, the anchor includes expandable lip and skirt regions for engaging the patient's heart valve during deployment. In some embodiments, the anchor comprises a braid fabricated from a single strand of wire. In some embodiments, the apparatus includes a lock configured to maintain anchor expansion. The invention also includes methods for endovascularly replacing a patient's heart valve. In some embodiments, the method includes the steps of endovascularly delivering a replacement valve and an expandable anchor to a vicinity of the heart valve, wrapping at least a portion of the replacement valve about the anchor, and expanding the anchor to a deployed, configuration.

Methods and apparatus are provided for protecting the external ear from the elements, heat, cold, wind, rain and/or snow. In some embodiments, an ear protector comprises a conforming anchor with an opening through which the external ear may be passed. The ear protector further comprises an insulating outer covering that, in combination with the anchor, forms the ear protector with a chamber positioned between the outer covering and the anchor. During use, the chamber is configured to receive the external ear, with the anchor's opening conformably positioned in proximity to at least a portion of the ear's root. The perimeter of the conforming anchor's opening resiliently deforms during passage of the external ear through the opening and into the chamber, and then conforms to the geometry of at least a portion of the ear root in order to securely and comfortably maintain the ear protector in position over the external ear without additional external support. The conforming anchor preferably is fabricated from a closed cell foamed elastomer.

Methods and apparatus for ear protection

Apparatus for manipulating and securing tissue are described herein. In creating tissue folds within the body of a patient, a tissue manipulation assembly may generally have an elongate tubular member, an engagement member slidably dispose through the tubular member and a distal end adapted to engage tissue via a helical member, tissue stabilizing members positioned at the tubular member distal end which are adapted to stabilize tissue therebetween, and a delivery tube pivotable about the tissue stabilizer. The stabilizing members can be adapted to become angled relative to longitudinal axis of the elongate tubular member. Moreover, one or all the articulation controls and functions can be integrated into a singular handle assembly connectable to the tissue manipulation assembly via a rigid or flexible tubular body.

Apparatus for manipulating and securing tissue

Methods and apparatus are provided for point-of-care nucleic acid amplification and detection. One embodiment of the invention comprises a fully integrated, sample-to-answer molecular diagnostic instrument that optionally may be used in a multiplexed fashion to detect multiple target nucleic acid sequences of interest and that optionally may be configured for disposal after one-time use. The instrument preferable utilizes an isothermal nucleic acid amplification technique, such as loop-mediated isothermal amplification (LAMP), to reduce the instrumentation requirements associated with nucleic acid amplification. Detection of target amplification may be achieved, for example, via detection of a color shift or fluorescence in a dye added to the amplification reaction. Such detection may be performed visually by an operator or may be achieved utilizing an imaging technique, e.g., spectrophotometric imaging.

Methods and apparatus for point-of-care nucleic acid amplification and detection

A device for modifying tissue in a spine may include: a shaft having a proximal portion and a distal portion, the distal portion having dimensions which allow it to be passed into an epidural space of the spine and between target and non-target tissues; at least one distal force application member extending from the distal portion of the shaft and configured to facilitate application of at least one of anchoring force and tensioning force to the shaft; at least one movable tissue modifying member coupled with the shaft at or near its distal portion; at least one drive member coupled with the at least one tissue modifying member to activate the at least one tissue modifying member; and at least one power transmission member coupled with the at least one drive member to deliver power to the at least one drive member.

Powered tissue modification devices and methods

Apparatus is provided for sealing a vascular puncture by causing a reduction in the circumference of the puncture tract through delivery of a closure agent into tissue surrounding the puncture tract. A resultant inflammatory response and volumetric increase cause the tissue to swell into the puncture tract, thereby sealing it.

Apparatus for sealing a puncture by causing a reduction in the circumference of the puncture

The present invention provides methods and apparatus for endovascularly replacing a patient's heart valve. The apparatus includes a replacement valve and an expandable anchor configured for endovascular delivery to a vicinity of the patient's heart valve. In some embodiments, the replacement valve is adapted to wrap about the anchor, for example, by everting during endovascular deployment. In some embodiments, the replacement valve is not connected to expandable portions of the anchor. In some embodiments, the anchor is configured for active foreshortening during endovascular deployment. In some embodiments, the anchor includes expandable lip and skirt regions for engaging the patient's heart valve during deployment. In some embodiments, the anchor comprises a braid fabricated from a single strand of wire. In some embodiments, the apparatus includes a lock configured to maintain anchor expansion. The invention also includes methods for endovascularly replacing a patient's heart valve. In some embodiments, the method includes the steps of endovascularly delivering a replacement valve and an expandable anchor to a vicinity of the heart valve, wrapping at least a portion of the replacement valve about the anchor, and expanding the anchor to a deployed configuration.

Apparatus and methods for manipulating and securing tissue are described herein. In creating tissue folds within the body of a patient, a tissue manipulation assembly may generally have an elongate tubular member, an engagement member slidably disposed through the tubular member and a distal end adapted to engage tissue via a helical member, tissue stabilizing members positioned at the tubular member distal end which are adapted to stabilize tissue therebetween, and a delivery tube pivotable about the tissue stabilizer. The stabilizing members can be adapted to become angled relative to a longitudinal axis of the elongate tubular member. Moreover, one or all the articulation controls and functions can be integrated into a singular handle assembly connectable to the tissue manipulation assembly via a rigid or flexible tubular body.

Apparatus and methods for manipulating and securing tissue

Methods and apparatus are provided for point-of-care nucleic acid amplification and detection. One embodiment of the invention comprises a fully integrated, sample-to-answer molecular diagnostic instrument that optionally may be used in a multiplexed fashion to detect multiple target nucleic acid sequences of interest and that optionally may be configured for disposal after one-time use. Optionally, sample preparation is fully or partially achieved via heat treatment and/or using a filter paper, such as a chemically treated filter paper, e.g., an FTA card. The instrument preferable utilizes an isothermal nucleic acid amplification technique, such as loop-mediated isothermal amplification (LAMP), to reduce the instrumentation requirements associated with nucleic acid amplification. Detection of target amplification may be achieved, for example, via detection of a color shift or fluorescence in a dye added to the amplification reaction.

Catheter apparatuses, systems, and methods for achieving renal neuromodulation by intravascular access are disclosed herein. One aspect of the present application, for example, is directed to apparatuses, systems, and methods that incorporate a catheter treatment device comprising an elongated shaft. The elongated shaft is sized and configured to deliver an energy delivery element to a renal artery via an intravascular path. Thermal or electrical renal neuromodulation may be achieved via direct and/or via indirect application of thermal and/or electrical energy to heat or cool, or otherwise electrically modulate, neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers.

Catheter apparatuses, systems, and methods for renal neuromodulation

Growing community of inventors

Livermore, CA, United States of America

Kenneth J Michlitsch