Merck + Co., Inc.

Kenneth J Fitch

Thomas F Walsh

Daljit S Dhanoa

William J Greenlee

Ralph A Rivero

David L Williams

Arthur A Patchett

Prasun K Chakravarty

Scott William Bagley

David G Hangauer

James R Tata

Nancy J Kevin

Richard B Toupence

Douglas J Pettibone

Theodore P Broten

Daniel F Veber

Elizabeth M Naylor

Anna Chen

Jay M Matthews

Richard L Tolman

Wallace T Ashton

Donald W Graham

Soumya P Sahoo

Alan D Adams

Derek J Von Langen

Conrad Santini

Gregory D Berger

Gerard R Kieczykowski

Joel Peter Berger

David E Moller

Mark D Leibowitz

Anthony B Jones

The instant invention is concerned with acetylphenols which are useful as antiobesity and antidiabetic compounds. Compositions and methods for the use of the compounds in the treatment of diabetes and obesity and for lowering or modulating triglyceride levels and cholesterol levels or raising high density lipoprotein levels or for increasing gut motility or for treating atherosclerosis are also disclosed.

Benzisoxazole-derived antidiabetic compounds

Phenoxyphenylacetic acid derivatives

Phenoxyphenylacetic acids and derivatives of the general structural formula I ##STR1## have endothelin antagonist activity and are useful in treating cardiovascular disorders, such as hypertension, postischemic renal failure, vasospasm, cerebral and cardiac ischemia, myocardial infarction, endotoxic shock, benign prostatic hyperplasia, inflammatory diseases including Raynaud's disease and asthma.

Biphenyl compounds useful or endothelin antagonists

Substituted heterocycles attached through a methylene bridge to novel substituted phenyl derivatives of the Formula I are useful as angiotensin II antagonists. ##STR1## wherein the substituents are as defined in the claims.

Angiotensin II antagonists incorporating a substituted benzyl element

Phenoxyphenylacetic acids and derivatives of general structural formula I ##STR1## have endothelin antagonist activity and are therefore useful in treating cardiovascular disorders, such as hypertension, postischemic renal failure, vasospasm, cerebral and cardiac ischemia, myocardial infarction, inflammatory diseases, Raynaud's disease, and endotoxic shock, and asthma.

Quinazolinones substituted with phenoxyphenylacetic acid derivatives

Phenoxyphenylacetic acids and derivatives of general structural formula I ##STR1## have endothelin antagonist activity and are therefore useful in treating cardiovascular disorders, such as hypertension, postischemic renal failure, vasospasm, cerebal and cardiac ischemia, myocardial infarction, inflammatory diseases, Raynaud's disease, and endotoxic shock, and asthma.

Phenoxyphenylacetic acids and derivatives of general structural formula I ##STR1## have endothelin antagonist activity and are therefore useful in treating cardiovascular disorders, such as hypertension, congestive heart failure, postischemic renal failure, vasospasm, cerebral and cardiac ischemia, myocardial infarction, inflammatory diseases, Raynaud's disease, and endotoxic shock, and asthma.

Six membered ring fused imidazoles substituted with phenoxyphenylacetic

Phenoxyphenylacetic acids and derivatives of general structural formula I have endothelin ##STR1## antagonist activity and are therefore useful in treating cardiovascular disorders, such as hypertension, congestive heart failure, postischemic renal failure, vasospasm, cerebral and cardiac ischemia, myocardial infarction, inflammatory diseases, Raynaud's disease, and endotoxic shock, and asthma.

Six-membered ring fused imidazoles substituted with phenoxyphenylacetic

Substituted heterocycles attached through a methylene bridge to novel substituted phenyl derivatives of the Formula I are useful as angiotensin II antagonists. ##STR1##

Quinazolinone, triazolinone and pyrimidinone angiotensin II antagonists

Angiotensin II antagonists incorporating a substituted pyridoimidazolyl

Substituted imidazoles attached through a methylene bridge to novel substituted phenyl derivatives of the Formula I, are useful as angiotensin II antagonists. ##STR1##

Imidazole angiotensin II antagonists incorporating a substituted benzyl

Substituted triazoles attached through a methylene bridge to novel substituted phenyl derivatives of the Formula I, are useful as angiotensin II antagonists. ##STR1##

Triazole angiotensin II antagonists incorporating a substituted benzyl

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Cranford, NJ, United States of America

Kenneth J Fitch