University of Texas System

Texas Instruments Corporation

University of North Texas

Samsung Sdi Co., Inc.

Northeastern University

Kenneth J Balkus, Jr

Mary E Kinsel

John Patrick Ferraris

Ashley Steve Scott

Alexi G Gabrielov

Bruce E Gnade

Duck Joo Yang

A Dean Sherry

Stuart W Young

Ying Ma

Anthony J Di Pasqua

Inga H Musselman

Scott J Riley

Yi Shi

Sudha Madhugiri

Imalka S Munaweera

Decio H Coutinho

Lisa L Washmon

Hyuk Jae Chang

Alexei Grigorievich Gabrielov

Hae-kyoung Kim

Geoffrey Davies

Wenjin Deng

Paul Pantano

Zhiwei Yang

Chalita Ratanatawanate

Dennis W Smith

Alysia Lowe

Dennis W Smith, Jr

Stanislaw Kowalak

Chamaal Karunaweera

Tarek M Abdel-Fattah

Thomas J Pisklak

Daniel K Dei

Grace Jones D Kalaw

Claudia C Meek

Nimanka Panapitiya

Babloo Sharma

Sumudu Wijenayake

Harvey A Liu

Iron garnet nanoparticles and or iron garnet particles containing various activatable nuclides, such as holmium-165 (Ho) and dysprosium-164 (Dy), are disclosed in this application. The iron garnet (e.g., HoIG and DyIG) nanoparticles and iron garnet particles can prepared using hydroxide co-precipitation methods. In some embodiments, radiosensitizers can be loaded on radioactive magnetic nanoparticles or radioactive iron garnet particles and, optionally, coated with suitable lipid bilayers. Methods of using the disclosed nanoparticles and particles for mediating therapeutic benefit in diseases responsive to radiation therapy are also provided. Another aspect of the invention provides films, electrospun fabrics or bandage coverings for the delivery of radiation to the site of a skin lesion amenable to treatment with radiation (e.g., skin cancers or psoriasis).

Iron garnet nanoparticles for cancer radiotherapy and chemotherapy

In some aspects, the present disclosure provides a polymer composition which comprises two polymer molecules and a compatibilizing agent. In some embodiments, the polymer composition is useful for the preparation of membranes used in the separation of two or more gases. In some embodiments, the polymer composition comprises a polyimide polymer and a polybenzimidazole polymer which have been compatibilizing with a small molecule or a metal organic framework.

Compatibilized immiscible polymer blends and molecular sieve membranes thereof

An aspect of the invention is directed to a polymer comprising a sulfonated perfluorocyclopentyl compound. Another aspect of the invention is directed to a sulfonated copolymer comprising one or more sulfonated polymers. A further aspect of the invention is directed to membranes prepared from the polymers of the claimed invention.

Sulfonated perfluorocyclopentenyl polymers and uses thereof

The present disclosure describes compositions operable for releasing nitric oxide under photochemical conditions. The compositions include a titanium dioxide nanomaterial and a nitric oxide-releasing compound deposited on the titanium dioxide nanomaterial that is operable to release nitric oxide under photochemical conditions. Titanium dioxide nanomaterials include, for example, titanium dioxide nanotubes. To facilitate the photochemical release of nitric oxide, some embodiments of the compositions further include a semiconductor that is deposited on the titanium dioxide nanotubes. Both the semiconductor and the nitric oxide-releasing compound may be deposited on the interior surface, exterior surface, or both of the titanium dioxide nanotubes. A polymer may wrap the titanium dioxide nanotubes to protect the nitric oxide-releasing compounds from moisture. Also disclosed herein are methods for producing such compositions and medical devices obtained therefrom.

Titanium dioxide nanotubes for production and delivery of nitric oxide and methods for production thereof

The present disclosure describes compositions providing for controlled release of nitric oxide (NO) and methods for production of these compositions. In some embodiments, the compositions may include a biodegradable polymer and a nitric oxide-releasing material at least partially encapsulated by the biodegradable polymer. Nitric oxide-releasing materials may include, for example, diazeniumdiolates and nitric oxide contained within a zeolite, metal-organic framework or other porous material. In general, the compositions are spun into a porous fiber, which may be further annealed by heating in order to densify the fiber. Annealing may prolong the NO release profile. Medical devices containing the compositions described herein are also contemplated by the present disclosure. Medical devices include, for example, textiles, bandages and articles of clothing.

Compositions and medical devices for controlled release of nitric oxide and methods of production thereof

The invention relates to nitric oxide-releasing compositions comprising polyacrylonitrile polymers that are diazeniumdiolated, and to medical devices comprising such compositions, as well as to methods of making and using the compositions and medical devices.

Nitric oxide-releasing compositions and methods

Low vapor pressure compound-based fuels are provided. These fuels are useful in catalytic burner systems that can be used to disperse fragrances, insecticides, insect repellants (e.g., citronella), aromatherapy compounds, medicinal compounds, deodorizing compounds, disinfectant compositions, fungicides and herbicides.

Low vapor pressure fuels for use in catalytic burners

Electrospun fibers comprising mesoporous molecular sieve materials are described. In an aspect of the invention, fibers are electrospun from a conducting solution to which a high voltage electric current is applied. The apparatus includes in one aspect one or more conducting solution introduction devices for providing a quantity of conducting solution, said conducting solution introduction devices being electrically charged thereby establishing an electric field between said conducting solution introduction devices and a target, and means for controlling the flow characteristics of conducting solution from said one or more conducting solution introduction devices.

Electrospun mesoporous molecular sieve fibers

A polymer electrolyte forming composition includes a trialkoxysilane containing an epoxy group, polyethyleneimine, and at least one of heteropolyacid and trifluoromethanesulfoneimide.

Polymer electrolyte and fuel cell using the same

The present invention encompasses novel mesoporous compositions comprising vitamin E and alumina, and methods for their synthesis. The mesoporous compositions of the present invention have applications as drug-delivery vehicles.

Mesoporous compositions for use in drug delivery

The invention is directed to an apparatus and methods for electrospinning composite fibers including polymeric material and mesoporous molecular sieve material. The methods include in one aspect electrospinning fibers from a conducting solution to which a high voltage electric current is applied. The apparatus includes in one aspect one or more conducting solution introduction devices for providing a quantity of conducting solution, the conducting solution introduction devices being electrically charged thereby establishing an electric field between the conduction solution introduction devices and a target, and means for controlling the flow characteristics of conducting solution from the conducting solution introduction devices.

Electrospinning of polymer and mesoporous composite fibers

A molecular sieve particle-based analytic chemistry system is disclosed in which populations of encoded molecular sieve particles carrying different chemical functionalities are distributed into wells etched in an optical fiber bundle. The chemical functionalities are encoded on separate shaped molecular sieve particles using luminescent dyes and/or molecular sieve particle shapes and thus, a single sensor array may carry thousands of chemistries. Such encoded molecular sieve particles can provide at least a five-fold enhancement in tunable parameters for increasing the encoding possibilities of high throughput screening assays relative to the present dye-modified polymeric microsphere standard.

Encoded molecular sieve particle-based sensors

The present invention encompasses novel mesoporous compositions comprising vitamin E, and methods for their synthesis. The mesoporous compositions are synthesized in a range of conditions to produce varied morphologies including, but not limited, to gyroids, hexagons, hexagonal rods, discs, and spheres.

Mesoporous compositions and method of preparation

Growing community of inventors

The Colony, TX, United States of America

Kenneth J Balkus, Jr