Serenex, Inc.

Esanex, Inc.

Kenneth He Huang

James Marvin Veal

Thomas E Barta

Gunnar J Hanson

Lindsay A Hinkley

Jeron Eaves

Lifeng Geng

Emilie Despagnet Smith

Wei Ma

Andy Ommen

Disclosed are compounds and pharmaceutically acceptable salts of Formula I wherein R, R, R, R, R, R, R, n, Q, Q, Q, Y, and X-Xare as defined herein. Compounds of Formula I are useful in the treatment of diseases and/or conditions related to cell proliferation, such as cancer, inflammation, arthritis, angiogenesis, or the like. Also disclosed are pharmaceutical compositions comprising compounds of the invention and methods of treating the aforementioned conditions using such compounds.

Benzene, pyridine, and pyridazine derivatives

The current invention is directed toward compounds and pharmaceutically acceptable salts of Formula I wherein Qis CR, Qis N, Qand Qare each CR, Qis CR, Xis N or CRc, Y is CR, Xand Xare each C(R)(R), Ris O. Compounds of Formula I are useful in the treatment of diseases and/or conditions related to cell proliferation, such as cancer The current invention is also directed toward pharmaceutical compositions comprising compounds of the invention.

Quinazoline derivatives for the treatment of cancer

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Chapel Hill, NC, United States of America

Kenneth He Huang