Children's Hospital Medical Center

Kenneth H Gabbay

Paul M Gallop

A method of measuring glycosylated hemoglobin featuring, in one aspect, providing a sample containing hemoglobin, including an unknown amount of glycosylated hemoglobin, contacting the sample with an oxidizing agent to generate formaldehyde, and measuring the formaldehyde as a measure of glycosylated hemoglobin, the measuring being carried out by reacting the formaldehyde with a water-soluble amine or an ammonium salt and a .beta.-diketone to generate a fluorescent compound whose fluorescence is measured as a measure of glycosylated hemoglobin.

Glycohemoglobin determination

Process and apparatus for measuring glycosylated hemoglobin by assaying bound glyco groups in hemolysate featuring, in one aspect, appropriate oxidation of glycosylated hemoglobin and the rapid measurement of the resultant aldehydic compounds.

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Chestnut Hill, MA, United States of America

Kenneth H Gabbay