Other

Mayo Foundation for Medical Education and Research

Kenneth H Brookler

Jan Stepanek

Michael J Cevette

Gaurav N Pradhan

Jamie M Bogle

Samantha J Kleindienst

Techniques for generating and administering an oculo-cognitive addition test. Some aspects include identifying, by a system, a set of numbers that are to be displayed to a user during a trial of a cognitive test. The set of numbers includes at least two numbers. The system can administer the trial of the cognitive test, including, for each number in the set of numbers: displaying the number at a particular position of a display environment; tracking, by the system and using one or more optical sensors, eye movement of the user seeking the number in the display environment; and receiving, by the system and after having displayed the number for a time, a command that is to advance or end the cognitive test.

Oculo-cognitive addition testing

An electrode includes a body and a breakable container of contact-enhancing fluid on or in the body. The container is impermeable to the fluid, and is breakable in response to physical manipulation of the electrode to disperse the fluid into the body.

Electrophysiological and stimulation electrode

A method of treating otosclerosis in a human in need thereof by administering a bisphosphonate in a defined dosing schedule. The invention demonstrates an effective response and sustained benefit in the treatment of otosclerosis. Particularly, the method involves administration of a bisphosphonate in a stepped-up dosage amount, e.g., in a dose that is at least one and a half times the recommended dose for osteoporosis. It also includes administration of a time-dependent dose of more than one bisphosphonate, specifically, alternating administration of a first bisphosphonate with a second bisphosphonate. The inventive method further includes intravenous administration of a bisphosphonate, and optionally oral administration of a bisphosphonate. The present invention further contemplates a kit for facilitating the alternating bisphosphonate dosing schedule.

Use of bisphosphonates for otosclerosis

A method of treating otosclerosis in a human in need thereof by administering a bisphosphonate in a defined dosing schedule. The invention demonstrates an effective response and sustained benefit in the treatment of otosclerosis. Particularly, the method involves administration of a bisphosphonate in a stepped-up dosage amount, e.g., in a dose that is at least one and a half times the recommended dose for osteoporosis. It also includes administration of a time-dependent dose of more than one bisphosphonate, specifically, alternating administration of a first bisphosphonate with a second bisphosphonate. The inventive method further includes intravenous administration of a bisphosphonate, and optionally oral administration of a bisphosponate. The present invention further contemplates a kit for facilitating the alternating bisphosphonate dosing schedule

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Norwalk, CT, United States of America

Kenneth H Brookler