Optiscan Biomedical Corporation

Greyhawk Systems, Inc.

Sharp Corporation

Kenneth G Witte

James Roswell Braig

Martin J Fennell

W Dale Hall

Bernhard B Sterling

Peng Zheng

Bryan E Loucks

Richard L Keenan

Daniel S Goldberger

Peter Rule

Frederic J Kahn

Jerry Leff

David E Stepner

Linden J Livoni

Paul N Kendrick

Jennifer H Gable

Mark Wechsler

Philip C Hartstein

Julian M Cortella

Robert P Harshberger, Jr

Kenneth I Li

Richard A King

David N Callicoat

Mark D Agostino

Robert D Gaffney

Roger O Herrera

Heidi M Smith

Mike A Munrow

David Klonoff

Jane J Sheill

A method and apparatus are described that permit an analyte concentration to be estimated from a measurement in the presence of compounds that interfere with the measurement. The method reduces the error in the analyte concentration in the presence of interferents. The method includes the use of a set of measurements obtained for a large population having a range of known analyte and interfering compound concentrations. From a sample measurement, which may or may not be one of the population, likely present interferents are identified, and a calibration vector is calculated.

Method and apparatus for determining an analyte concentration in a sample having interferents

An apparatus for analyzing the composition of bodily fluid. The apparatus comprises a fluid handling network including a patient end configured to maintain fluid communication with a bodily fluid in a patient; and a pump unit in operative engagement with the fluid handling network. The pump unit has an infusion mode in which the pump unit is operable to deliver infusion fluid to the patient through the patient end, and a sample draw mode in which the pump unit is operable to draw a sample of the bodily fluid from the patient through the patient end. The apparatus further comprises a spectroscopic analyzer positioned to analyze at least a portion of the sample; a processor in communication with or incorporated into the spectroscopic analyzer; and stored program instructions executable by the processor to obtain measurements of two or more properties of the sample. In one implementation, the pump unit comprises a first pump operable in the infusion mode but not in the sample draw mode, and a second pump operable in the sample draw mode but not in the infusion mode.

Analyte detection system for multiple analytes

A method determines an analyte concentration in a sample including the analyte and a substance. The method includes providing an absorption spectrum of the sample. The absorption spectrum has an absorption baseline. The method further includes shifting the absorption spectrum so that the absorption baseline approximately equals a selected absorption value in a selected absorption wavelength range. The method further includes subtracting a substance contribution from the absorption spectrum. Thus, the method provides a corrected absorption spectrum substantially free of a contribution from the substance.

Method of determining an analyte concentration in a sample from an absorption spectrum

A reagentless whole-blood analyte detection system that is capable of being deployed near a patient has a source capable of emitting a beam of radiation that includes a spectral band. The whole-blood system also has a detector in an optical path of the beam. The whole-blood system also has a housing that is configured to house the source and the detector. The whole-blood system also has a sample element that is situated in the optical path of the beam. The sample element has a sample cell and a sample cell wall that does not eliminate transmittance of the beam of radiation in the spectral band.

Reagent-less whole-blood glucose meter

A device and method are provided for use with a noninvasive optical measurement system, such as a thermal gradient spectrometer, for improved determination of analyte concentrations within living tissue. In one embodiment, a wearable window is secured to a patient's forearm thereby isolating a measurement site on the patient's skin for determination of blood glucose levels. The wearable window effectively replaces a window of the spectrometer, and thus forms an interface between the patient's skin and a thermal mass window of the spectrometer. When the spectrometer must be temporarily removed from the patient's skin, such as to allow the patient mobility, the wearable window is left secured to the forearm so as to maintain a consistent measurement site on the skin. When the spectrometer is later reattached to the patient, the wearable window will again form an interface between the spectrometer and the same location of skin as before.

Device for capturing thermal spectra from tissue

An analyte detection system non-invasively determines the concentration of an analyte in a sample generating a sample infrared signal indicative of the concentration of the analyte in the sample. The detection system includes a window assembly for receiving the sample infrared signal. The window assembly is adapted to allow the sample infrared signal to transmit therethrough, and generates a window infrared signal. The detection system further includes at least one detector configured to receive both the window infrared signal and the sample infrared signal transmitted through the window assembly. The detector is further adapted to generate a detector signal in response thereto. The detection system further includes a correction module configured to generate a corrected detector signal indicative of the concentration of the analyte in the sample.

Method and apparatus for adjusting signal variation of an electronically controlled infrared transmissive window

A device and method for determining analyte concentrations within a material sample are provided. A modulating temperature gradient is induced in the sample and resultant, emitted infrared radiation is measured at selected analyte absorbance peaks and reference wavelengths. The modulating temperature gradient is controlled by a surface temperature modulation. A transfer function relating the surface temperature modulation to a modulation of the measured infrared radiation is provided. Phase and magnitude differences in the transfer function are detected. These phase and magnitude differences, having a relationship to analyte concentration, are measured, correlated and processed to determine analyte concentration in the material sample. A method for adjusting an analyte measurement is provided. The method provides a hydration correction process for calibration and correction whereby analyte concentrations within the material sample may be determined. The hydration correction process is particularly suitable for determining blood analyte concentrations within human tissue.

Method for adjusting a blood analyte measurement

An image projection apparatus in which an image object plane contains a plurality of reflecting images and a light source and optical system projects a beam on each of said plurality of images. Spaced projection lenses are positioned to receive the light reflected from the images and direct the light on a projection surface with the plurality of reflected images in coregistration.

Apparatus and method of forming and projecting high precision optical

An image projection apparatus in which an image object plane contains a plurality of reflecting images and a light source and optical system projects a beam on each of said plurality of images. Spaced projection lenses are positioned to receive the light reflected from the image and direct the light on a projection surface with the plurality of reflected images in coregistration.

An apparatus for projecting high precision optical images with a selective heating source, advantageously a laser, on a writable, erasable, editable electronic slide and simultaneously or sequentially projecting the images in registration, onto a receiving surface such as a projection screen or photosensitive material, in the former case for the purpose of displaying the projected image and in the latter case for the purpose of creating a hard copy of the projected image.

The position and motion of a rotating element is determined by using a two-grating moire pattern. Movement of the element causes a projected scale image representing radiation reflected from the element to shift relative to a fixed grating thereby generating moire fringes. The accumulated fringes serve to measure absolute position and motion of the element.

Apparatus for detecting position of a rotating element using a

The position of a rotating element is controlled by a galvanometer and a servo system. The position of the rotating element is determined by using a two-grating moire pattern. Movement of the element causes a projected scale image representing radiation reflected from the element to shift relative to a fixed grating thereby generating moire fringes. The accumulated fringes serve to measure absolute position and motion of the element. The servo digitally processes the measured position to generate several force components which are then combined to control the amount of force applied by the galvanometer to rotate the element.

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San Jose, CA, United States of America

Kenneth G Witte