Amgen Inc.

Kenneth G Schalhoub

Wael Mismar

Shaun Robert Devitt

Jessica Hai Liu

Chia-Jung Wu

Anthony Bitong

Malak Guirguis

Dylan Bourelle

Mads Schjoth Due

Shermeen A Abbas

Rami Saifan

Tej Desai

Arin Keshishian

Chelsea Balli-Cruz

Pierre Burquel

Ryan Oba

A method of externally sterilizing a drug delivery device utilizing Nitrogen Dioxide (NO2) is provided, including placing the drug delivery device in a sterilization chamber, introducing into the chamber a dose of NO2 having a concentration of between about 2 and 20 milligrams per Liter by applying a vacuum level of between about 10 and 600 Torr and holding the vacuum level for a dwell time of between about 2 and 20 minutes, repeating the step of introducing into the chamber a dose of NO2 for a number of pulses between about 1 and 24, purging the sterilization chamber of at least substantially all of the NO2, and aerating the sterilization chamber.

Method for external sterilization of drug delivery device

An injection device is provided, including a syringe having a barrel and a flange and a backstop configured to be coupled with the syringe adjacent to the flange. The backstop includes an inner surface generally extending around at least a portion of the syringe, wherein the inner surface includes at least one protrusion extending away from the inner surface and configured to engage the flange and/or the barrel to permit or promote airflow through a space between the inner surface and the syringe.

Injection device for drug delivery and packaging for the injection device

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Denver, CO, United States of America

Kenneth G Schalhoub