Becton Dickinson and Company Limited

General Electric Company

Other

Kenneth G Powell

John M Polidoro

Carl R Sahi

P Spencer Kinsey

Charles D Shermer

Vincent J Sullivan

Matthew S Ferriter

Ge Jiang

Chad C Smutney

Robert I Connelly

James Fentress

David S Chapin

Alexander George Lastovich

Daniel M Stipe

Burton H Sage, Jr

Robert H Wildi

Jack A Hill

Jeff M Moss

Larry A Monahan

Ed Browka

Melody Kuroda

Greg R Bradtke

Sterling B Brown

James S Bates

John Robert Campbell

Min Wei

Michael L King

William David Richards

Joseph C Golba, Jr

Ying Xu

Spencer P Kinsey

Vinod Kumar Berry

Jack Lew Little

Catherine Marie Pottier-Metz

Montgomery Meigs

Linda McAdam Gemmell

Jeff Moss

James K Fentress

Robert Connelly

Jim Fentress

A wearable, self-contained drug infusion device is disclosed that is capable of achieving the precise flow rate control needed for dose-critical drugs such as insulin. In preferred embodiments of the device, at least two flow channels are utilized in conjunction with a series of valves for providing a user with selectable, constant flow rate control. The device can be made with small dimensions so that it can be worn by the user with a minimum of discomfort and inconvenience. In addition, the simple mechanical nature of the device provides the user with close control over the flow rate, which is required for safe and effective delivery of insulin and other drugs. Also, the absence of electronic components allows the device to be manufactured inexpensively. The device is provided with a first channel that is long and narrow, functioning as a flow restrictor. The first channel is preferably provided in a serpentine pattern. A second channel is also provided that has a larger cross section so that flow is not restricted. A series of valves are used to force the flow of fluid through a selectable portion of the serpentine portion of the first channel before entering the remainder of the second channel and flowing to the delivery cannula. In one embodiment of the device, a needle port is provided in fluid communication with the delivery cannula for delivering bolus injections. In another embodiment, a bolus button is provided for delivering bolus injections. A flow restrictor is preferably included in the bolus button to limit the rate at which the bolus button refills.

Constant rate fluid delivery device with selectable flow rate and titratable bolus button

A system and method for a patch-like, self-contained multi-component substance infusion device which provides one or more substantially hidden patient needles which can be placed in fluid communication with a fluid reservoir assembly that includes a rigid bladder portion used in conjunction with a non-distensible bladder film, such as a metallized film. The device can be attached to a skin surface via an adhesive contact and a pressurization system provides a pressure to the contents of a fluid reservoir assembly. Improvements to dry powdered formulations for reconstitution for preferred use in the device are also disclosed.

Reconstituting infusion device

A pen body assembly () for a drug delivery pen includes a pen body () and a dose setting body () movably connected to the pen body (). A knob () is connected to the dose setting body () for moving the dose setting body () relative to the pen body (). One of the pen body () and the dose setting body () has a thread groove () having a varied pitch disposed thereon and the other one has a protrusion () engaging the thread groove ().

Injection pen for intradermal medication injection

A device, system and method is provided for dispersing an aerosol formulation comprising a medicament. The device may be useful in administering inhaleable vaccines and the like. The device designed for low cost and applicability to a multitude of patient populations. The device has a spacer () is suitable for use with a wide range of aerosolized formulations, particularly powders. The spacer () may be an expandable volume spacer (). The spacer () may also be used with other inhalation aids (). The spacer () may include a multi-purpose outlet () for use with different groups within the target patient population.

Disposable spacer for inhalation delivery of aerosolized drugs and vaccines

A system and method for a patch-like, self-contained substance infusion device which provides one or more substantially hidden patient needles which can be placed in fluid communication with a fluid reservoir subassembly that includes a rigid bladder portion used in conjunction with a non-distensible bladder film, such as a metallized film. Simple removal of an interlock allows a disk, or Belleville spring assembly to apply an essentially even and constant pressure to the contents of the fluid reservoir assembly, and allows the device to then be attached to a skin surface via an adhesive contact surface. A push button activation assembly is provided which can then be used to release and seat one or more spring-loaded patient needles into the skin surface, and establish a fluid communication path between the patient needles and the pressurized fluid reservoir contents thereby delivering an infusion into the skin.

Patch-like infusion device

A fluid delivery device for delivering a substance to a patient by way of infusion delivers the preparation at a rate of flow which varies in steps from a substantially constant higher rate, to a stepped-down substantially constant lower rate or rates. The delivery device includes one or more reservoirs, and one or more Belleville springs for applying generally constant pressures to the substance contained in the reservoirs. Each reservoir will have a different constant pressure applied in a mid-range of operation. The reservoirs can be interconnected to each other and to an infusion device in a number of arrangements, including various manifolds and flow restrictors, such that the rate of flow is controlled in steps in accordance with the pressures applied by the springs of the plurality of reservoirs.

Multi-stage fluid delivery device and method

Methods for filling and sealing containers having one or more flexible sides. Non-standard containers for holding fluid are releasably supported during the filling and sealing process. Both the interior and exterior of the filled container are subjected to an environment of reduced pressure to minimize the headspace and sealed.

Method for filling a container having at least one flexible component

A device, preferably a micro-device, is molded from a plastic material by injection molding, compression molding or embossing. A microabrader can be molded having microneedles for abrading the stratum corneum of the skin to form an abraded site in the tissue for enhancing drug delivery. The micro-device is molded using a mold assembly having a silicon molding surface. The silicon molding surface can include a recess corresponding to the desired shape and length of the microneedles. The silicon molding surface enables micron and submicron size features to be molded from polymeric materials without the polymeric material adhering to the mold surface. Micro-devices having molded features having micron and submicron dimensions can be rapidly produced without the use of a release agent.

Method and apparatus for manufacturing a device

Growing community of inventors

Raleigh, NC, United States of America

Kenneth G Powell