Sclavo Spa

Kenneth G Mugridge

Rivo Presentini

Egle Solito

Cristina Becherucci

Mauro Perretti

Luca Parente

The synthetic peptide of formula (I) H-Ser-His-Leu-Arg-Lys-Val-Phe-Asp-Lys-OH (SEQ ID NO. 1) and its physiologically acceptable organic or inorganic salts are novel. The synthetic peptide (I), whose amino acid sequence corresponds to that of the sequence 204-212 of human lipocortin V, shows in vitro the capability of inhibiting the prostaglandin E2 release and in vivo an antiinflammatory activity. The peptide and its organic and inorganic salts are useful as therapeutic agents for the treatment of dermatological and collagen inflammatory infections.

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Casciano di Murlo, Italy

Kenneth G Mugridge