Millipore Corporation

Emd Millipore Corporation

Kenneth G Desilets

Joseph P Lane

Donald B Rising

Christopher A Scott

Chris Scott

Todd Taylor

Louis L Bonhomme

Rob Colonna

Thomas G Zermani

Richard Burnham

Stéphane Jean Marie Olivier

Daniel Morgan

Steven D Sheridan

Douglas A Boucher

Luc Lirot

Underdrain design for a multiwell device that when fixed to the device (either as an integral or removable component thereof), allows for adequate venting during filtration, minimizes or prevents air lock, and has improved structural integrity. Also disclosed is a laboratory device designed particularly for a multiplate format that includes a plate or tray having a plurality of wells, and an underdrain in fluid communication with each of the plurality of wells. The underdrain can be a separate, removable piece, or can be an integral unitary structure with the plate or tray forming a one-piece design. The design is preferably in compliance with SBS format.

Support and stand-off ribs for underdrain for multi-well device

The present invention provides an underdrain having an improved spout. The underdrain has particular utility in the construction of both single-well and microarray filtration devices. In a principal embodiment, the underdrain is characterized by its incorporation of a straight-walled, roughly-textured spout, the spout being provided with microhole(s) at a terminal end thereof for the discharge of fluid conducted through the underdrain. An array comprising several of such underdrains can be mated with a corresponding array of wells, with separation material (e.g., membrane material) provided therebetween. The resultant microarray filtration device can be used for conducting several fluid assays contemporaneously with, for example, good 'pendant drop' control and low 'cross-talk'.

Underdrain useful in the construction of a filtration device

A filter punch construction is provided for use in conjunction with a multiwell filtration device wherein each well includes a filtration membrane. The punch has a leading surface to which is secured an elongated piercing member having a sharp point and a periphery comprising holding or cutting edges and a following surface which has a guide member. The piercing member and cutting edges pierce the filtration membrane in each well and push the entire filter and retentate thereon into a receptacle vial.

Filter punch and filter collection system

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Westford, MA, United States of America

Kenneth G Desilets