Prothena Biosciences Limited

Genentech, Inc.

Genetech, Inc.

Kenneth Flanagan

Theodore A Yednock

Jeanne E Baker

Robin McDaid Barbour

Yue Liu

Stephen Jed Tam

Lian Mo

Lauri Diehl

Jeanne Baker

The invention provides antibodies that specifically bind to the LG4-5 modules of the G domain of laminin &#x3b1;4. The antibodies can preferentially stain cancer or tumor cells or tissue. The antibodies can be used for detecting cancer, evaluating the efficacy of a cancer therapy, treating cancer, and treating obesity or obesity-related diseases, among other applications.

Anti-Laminin4 antibodies specific for LG4-5

Anti-laminin4 antibodies specific for LG4-5

Described herein are anti-MCAM antibodies and antigen binding fragments thereof that are capable of inhibiting the interaction between MCAM and its ligand, a protein comprising a laminin &#x3b1;-4 chain. These anti-MCAM antibodies and antigen binding fragments thereof may be useful for, for example, treating inflammatory conditions characterized by the infiltration of MCAM-expressing cells into a site of inflammation in the body.

Anti-MCAM antibodies and associated methods of use

The present invention provides for a method of detecting the presence of inflammatory bowel disease in gastrointestinal tissues or cells of a mammal by detecting increased expression of LY6 genes in the tissues or cells of the mammal relative to a control.

Methods for detecting inflammatory bowel disease

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Alameda, CA, United States of America

Kenneth Flanagan