Wyckoff Chemical Company, Inc.

Kenneth E Anderson

A process for the isolation and purification of (RR,SS)-2-�(dimethylamino)methyl!-1-(3-methoxyphenyl)cyclohexanol and its salts from a Grignard reaction mixture which includes the (RR,SS) isomer, the (RS,SR) isomer and Grignard reaction side products. An aqueous solution of HBr is added to the reaction mixture to effect the selective precipitation of the (RR,SS) hydrobromide isomer from the mixture while the (RS,SR) isomer remains in solution. The precipitated (RR,SS)-2-�(dimethylamino)methyl!-1-(3-methoxyphenyl)cyclohexanol hydrobromide is converted to (RR,SS)-2-�(dimethylamino)methyl!-1-(3-methoxyphenyl)cyclohexanol hydrochloride.

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Allegan, MI, United States of America

Kenneth E Anderson