Baxter Travenol Laboratories, Inc.

Ferro Corporation

Other

Kenneth D Zabielski

Deenadayalu Chundury

Anthony S Scheibelhoffer

Timothy W Birch

Andrew M Rohn, Jr

Edward B Garver, Sr

James T Kempthorn

David V Bacehowski

Paul E Measells

Harold H Bowerman, Jr

L Steven Edge

The present invention provides a coextruded multilayer thermoplastic film structure for use in forming a medical fluid container such as an I.V. bag. A coextruded multilayer thermoplastic film structure according to the invention includes at least three layers. The first layer (A), which is the layer that contacts medical fluids such as, for example, saline solutions, lactated Ringers solutions, and the like, includes a mixture of a major part of a homopolymer or copolymer of polypropylene and a minor part of a block polymer of a vinyl aromatic monomer and a conjugated diene, a partially hydrogenated derivative thereof, or a selectively hydrogenated derivative thereof to which has been grafted a unsaturated carboxylic reagent. The second layer (B), which is melt bonded to the first layer (A), includes a block polymer of a vinyl aromatic monomer and a conjugated diene, a partially hydrogenated derivative thereof, or a selectively hydrogenated derivative thereof to which has been grafted a unsaturated carboxylic reagent. The third layer (C), which is melt bonded to the second layer (B), includes a homopolymer or copolymer of polypropylene.

Medical multilayer film structure

The present invention provides an adhesive composition for use in bonding a polymeric fitting to an olefin-containing component of an article used in medical applications. The adhesive composition according to the invention includes an adhesive polymer system dissolved in a solvent system. The solvent system includes an organic solvent having a solubility parameter within the range of from about 7.5 to about 10 (cal/cm ) . Subsequent to forming a bond between the polymeric fitting and the olefin-containing component, the adhesive composition can meet the requirements for USP Class VI materials. In a preferred embodiment of the invention, the adhesive composition includes a low shear mixture of an adhesive polymer system including an atactic polypropylene and a low density polyethylene that is dissolved in a solvent system including a blend of d-limonene and a ketone selected from the group consisting of 4-heptanone and cyclohexanone. The adhesive composition can be used, for example, to bond polymeric fittings made of materials such as, but not limited to, acrylic, polycarbonate, polyvinyl chloride, polyolefin, acrylonitrile butadiene-styrene, and polyester, to olefin-containing components of articles used in medical applications such as, but not limited to, tubing.

Adhesive composition primarily intended for use in medical applications

This invention relates to a solvent based adhesive composition including a major amount of a solvent system and a minor amount of an adhesive polymer system. The solvent system preferably includes a terpene and an aldehyde, ketone, or an aromatic solvent. The adhesive polymer system preferably includes one or a blend of polymers that dissolve, at least in part, in the solvent solution. The components of the solvent adhesive are compatible in that they do not separate upon standing. The solvent based adhesive composition provides good adhesion between polymer articles such as, for example, polyolefin and acrylic films, as well as good adhesion between polymeric articles and wood or metal substrates.

Solvent based adhesive composition

An injection site may be made of a disc of puncture-resealable rubber in which the periphery carries a coating of thermoplastic material which is bonded to a sealingly compatible surface to retain the injection site in position. The injection site may be made by coating a rod of puncture-resealable rubber with a plastic material, followed by transversely slicing the coated rod into discs, which may then be sealed to the sealingly compatible surfaces.

Method of manufacturing disc-shaped rubber articles, such as injection

An assembly for supporting a cannula comprises a hub which supports the cannula and which includes a post portion which concentrically surrounds a section of the cannula adjacent to the hub. The assembly also includes a cover which is attachable to the post portion of the hub to enclose the cannula. The cover and post portion are coupled together by a 'tamper-proof' connection which normally resists removal of the cover, and thereby attests to the sterile integrity of the needle. The connection can be broken in response to the deliberate application of a predetermined rotational force by the user upon the cover and cannot thereafter be recreated, thereby serving as an outward indication that the sterile integrity of the cannula has been compromised. Both the post portion and the cover remain physically intact, despite the breakage of the connection, to permit return of the cover when desired.

Assembly employing a breakable thermal bond which is not substantially

A method and apparatus for joining sealingly incompatible plastic materials is disclosed. A coextruded connector (10) with separate, telescopically related layers (12,14) is affixed to one of the materials. The outer layer (14) of connector (10) is composed of a polymer specifically selected to melt or deform at a temperature lower than that of inner layer (12). The connector is frictionally fit within a second material to be joined and the connection is heated to a temperature sufficient to melt or deform outer layer (14) without melting inner layer (12). Outer layer 14 is thereby securely fused to the second material or blood container. A secondary embodiment is disclosed for joining materials of similar composition. Two coextruded connectors (40,46), having telescopically related layers composed of different polymer materials, are formed, as above, but the layer sequence of each connector is opposite to the other. The connectors (40,46) are sized to frictionally fit one within the other and the layers (42,48) in facing contact are composed of a material selected to melt or deform at a temperature lower than the nonfacing layers (44,50). For joining, the connectors (40,46) are affixed to the materials to be joined and then fit one within the other. The connection is then heated to a temperature sufficient to cause the lower melting, facing layers (42,48) to fuse together.

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McHenry, IL, United States of America

Kenneth D Zabielski