Color Access, Inc.

Les Laboratoires Aeterna, Inc.

Elc Management LLC

E-l Management Corporation

Other

Estee Lauder Inc.

Kenneth D Marenus

Daniel H Maes

Edward Pelle

Thomas Mammone

Neelam Muizzuddin

Joseph Gubernick

Paul Brazeau

Christina G Fthenakis

Christina Juneau

Lieve Declercq

Vasile Ionita-Manzatu

Eric Dupont

Mirela Cristina Ionita-Manzatu

Andrew J Bevacqua

Gheorghe Cioca

Steven F Schnittger

Peter J Lentini

Geoffrey Hawkins

Liliana S George

Mary S Matsui

Jon Anderson

Nicolae Vrabie

Walter P Smith

Mindy S Goldstein

Chia Wen Chen

George Cioca

Peter S Lentini

H Peter Norden

Donald F Collins

&Eacute;ric Dupont

Richard B&eacute;liveau

Raffi Balian

Lavinia C Popescu

Nicholas J Pelliccione

Louis Punto

Glen Rein

The present invention relates to a topical or cosmetic system that includes a first element capable of acting as an electron donor and a second element capable of acting as an electron acceptor. Such first and second elements are spaced apart by a predetermined distance across a skin surface. The system also includes a third element extending over the predetermined distance across the skin surface, while the third element contains an electrically conductive medium for electrically connecting the first and second elements, thereby generating an electrical current that flows across the skin surface from the first element through the conductive medium to the second element in the absence of any power source. The present invention also relates to methods of using the above-described system for preventing or treating skin damage.

Microcurrent-generating topical or cosmetic systems, and methods of making and using the same

The invention relates to a method for improving skin lipid barrier function by applying to the skin a composition comprising effective amounts of a protease inhibitor and a cell differentiation enhancer. The composition is useful in promoting skin lipid barrier repair and maintaining the integrity of the lipid barrier. In this regard, the compositions can be used in the treatment and prevention of dry skin, and associated chrono/proto-aging conditions, in the treatment and prevention of irritation on the skin, in the treatment and prevention of UV-related damage to the skin, and in the enhancement of the retention of self-tanning.

Method and composition for improving skin barrier function

The present invention comprises cosmetic compositions and methods for retarding hair growth comprising a combination of an ornithine decarboxylase inhibitor, an anti-angiogenic active and an anti-inflammatory.

Cosmetic composition and method for retarding hair growth

The present invention relates to a cosmetic or pharmaceutical composition for topical application to the skin afflicted with rosacea and treated with a retinoid. The composition for treating rosacea comprises an anti-irritating component and several other components for treating rosacea. The other components form a mixture of a salicylic acid, a phytosphingosine, green tea, hinokitiol, gorgonian extract, and polysaccharide. The invention also provides a method for decreasing the irritation on the skin caused by the heightened sensitivity experienced by skin suffering from rosacea. The other components are effective in treating the rosacea condition, but particularly, in treating the telangiectasic symptom of rosacea.

Anti-irritating rosacea treatment

The present invention relates to cartilage extracts and to a method of producing the same. Shark cartilage extracts having anti-angiogenic, anti-tumor, anti-inflammatory and anti-collagenolytic activities have been obtained by an improved process. The process comprises the steps of obtaining a crude cartilage extract in an aqueous solution, this crude extract being fractionated to recover molecules of a molecular weight less than about 500 kDa. Some of the biologically active components of the extract are prepared by further fractionation. The cartilage extract can be used for treating diseases or conditions having etiological components selected from the group consisting of tumor proliferation, angiogenesis, inflammation, metalloprotease activity and collagenolysis. Several cosmetic applications based on the capacity of the liquid extract to improve skin conditions are also disclosed. A simple and efficient process for the preparation of cartilage extracts is also disclosed.

Shark cartilage extract: process of making, methods of using, and compositions thereof

The present invention relates to topical whitening compositions comprising a whitening effective amount of an Ascomycete-derived melanin-degrading enzyme extract and methods of preparing the composition. The compositions provide a whitening effect which occurs by degrading melanin in the skin, yet the compositions themselves do not turn dark in color. The enzyme extract can be derived from or from , and is added to the compositions of the present invention. The compositions containing the enzyme extract are twice as effective as kojic acid in producing a whitening effect on the skin.

Whitening compositions containing ascomycete derived enzyme

The present invention relates to topical compositions comprising a collagen enhancing effective amount of a whey protein, vitamin A, vitamin E and vitamin C in combination with each other. Vitamin E and vitamin C components are present in specific ranges based on their inverse effect in boosting collagen synthesis. The compositions can enhance the production of collagen in skin and improve the resiliency of the skin. The increased production of collagen using the compositions of the present invention restores proteins and vitamins to the skin and helps alleviate some of the effects of aging and photoaging of skin. The present invention also includes methods of applying the compositions to the skin.

Topical compositions containing whey proteins

The invention relates to composition having enhanced biological activity, the compositions comprising at least one structured water. In particular, the compositions contain a combination of I and S waters and a biologically active agent, in which the activity of the agent is increased relative to its activity in a non-structured water composition.

Structured water in cosmetic compositions

The invention relates to lipid mixture compositions comprising one or more cholesteryl esters in an amount of at least about 25% by weight of the composition, and less than about 5% by weight of sphingolipid, as well as cosmetic and pharmaceutical formulations for topical application to the lips containing the lipid mixture.

Lipid mix for lip product

The present invention relates to cosmetic or pharmaceutical compositions for topical application to the skin, the compositions comprising effective amounts of at least one of each of the antioxidants selected from the group consisting of (a) tocopherol and derivatives thereof, (b) ascorbic acid and derivatives thereof,(c) a butylated phenol, (d)N-acetyl cysteine, (e)a rosemary extract, and (f)ubiquinone and derivatives thereof. The compositions are useful in treating and preventing the symptoms of photoaging.

Antioxidant mixture comprising tocopherol

The present invention relates to cosmetic or pharmaceutical compositions for topical application to the skin, the compositions comprising effective amounts of at least one of each of the antioxidants selected from the group consisting of (a) tocopherol and derivatives thereof, (b) ascorbic acid and derivatives thereof, (c) a butylated phenol, (d) a rosemary extract, and (e)ubiquinone and derivatives thereof. The compositions are useful in treating and preventing the symptoms of photoaging.

Antioxidant mixture

The present invention relates to cartilage extracts and to a method of producing the same. Shark cartilage extracts having anti-angiogenic, anti-tumoral, anti-inflammatory and anti-collagenolytic activities have been obtained by an improved process. The process comprises the steps of obtaining a homogenate of cartilage in an aqueous solution, this homogenate being separated in a solid fraction (SOLID EXTRACT) and a liquid fraction which was further fractionated to obtain a LIQUID EXTRACT having molecules of a molecular weight comprised between 0 to 500 kDa. The composition of the liquid extract has then been investigated by different ways. Further fractionation of this extract led to the preliminary characterization of some of its active components. Due to the multiplicity of biological activities of the total liquid extract, it can be used for treating numerous diseases or conditions such as those having components selected from the group consisting of tumor proliferation, angiogenesis, inflammation and collagenolysis. Several cosmetic applications based on the capacity of the liquid extract to improve skin barrier function are also under the scope of this invention. These extracts have no offensive effect on normal body functions. Therefore, these shark cartilage extracts have a very promising therapeutic value. The process for the obtention of cartilage extracts is simple and efficient. The unexpectedly valuable products obtained by this process are therefore an indication of a new and non-obvious process.

Methods of using extracts of shark cartilage

The present invention relates to cartilage extracts and to a method of producing the same. Shark cartilage extracts having anti-angiogenic, direct anti-tumor proliferating, anti-inflammatory and anti-collagenolytic activities have been obtained by an improved process. The process comprises the steps of obtaining a homogenate of cartilage in an aqueous solution, this homogenate being centrifuged and further fractionated to obtain a total extract having molecules of a molecular weight comprised between 0 to 500 KDa. The composition of the liquid extract has then been investigated by different ways. Further fractionation of this extract led to the preliminary characterization of some of its active components. Due to the multiplicity of biological activities of the total liquid extract, it can be used for treating numerous diseases or conditions such as those having components selected from the group consisting of tumor proliferation, angiogenesis, inflammation and collagenolysis. This extract has no offensive effect on normal body functions. Therefore, this shark cartilage extract has a very promising therapeutic value. The process for the obtention of cartilage extracts is simple and efficient. The unexpectedly valuable products obtained by this process are therefore an indication of a new and non-obvious process.

Extracts of shark cartilage having anti-collagenolytic,

The invention relates to topical cosmetic or pharmaceutical compositions comprising an anti-stinging effective amount of an amino acid selected from the group consisting of an amino butyric acid, glutamine, glycine, and derivatives thereof, or mixtures thereof, as well as methods of reducing or preventing stinging using such compositions.

Composition and method for reducing stinging in skin

The disclosed invention is directed to methods and compositions for improving the rate, extent and lifetime of an artificially induced tanning of the human skin. The invention entails treating the skin with agents such as amino acids, dipeptides, and amino substituted containing polymers either prior to or simultaneously with application of dihydroxyacetone.

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Dix Hills, NY, United States of America

Kenneth D Marenus